normal phenotype
• mice exhibit no obvious abnormalities
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Allele Symbol Allele Name Allele ID |
Kremen1tm1Dgen targeted mutation 1, Deltagen MGI:3804430 |
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Summary |
3 genotypes
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• mice exhibit no obvious abnormalities
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• limb bone volume is increased compared to in wild-type mice but not compared to in Dkk1tm1Lmgd heterozygotes
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• mice have ectopic postaxial forelimb digits
• the frequency and size of ectopic digits is increase compared to in Kremen1tm1Dgen Kremen2tm1Cni homozygotes
• 40% of ectopic digits originate at the carpus like regular digits unlike in Kremen1tm1Dgen Kremen2tm1Cni homozygotes where ectopic digits originate from digit V
• however, unlike in Dkk1 null mice webbing of bone elements is not observed
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• while trabecular thickness is normal, the number of trabeculae is increased and trabecular separation is decreased compared to in wild-type mice
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• limb bone volume is double that in wild-type mice
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• bone forming osteoblast surface and osteoid surface are increased compared to in wild-type mice
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• mineral apposition rates are increased compared to in wild-type mice
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• bone formation rates are increased compared to in wild-type mice
• however, bone absorption is normal
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• mice have ectopic postaxial forelimb digits that are smaller or larger than digit V
• ectopic digits originate from digit V
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N |
• contrary to results using anti-sense inhibition, mice exhibit normal litter sizes and normal implantation
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 08/02/2024 MGI 6.24 |
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