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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Flt4tm2Ali
targeted mutation 2, Kari Alitalo
MGI:3804462
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Flt4tm2Ali/Flt4tm2Ali involves: 129S1/Sv * 129X1/SvJ * ICR MGI:3805316
ht2
 		Flt4tm2Ali/Flt4+ involves: 129S1/Sv * 129X1/SvJ * ICR MGI:3805317
ht3
 		Flt4tm1Ali/Flt4tm2Ali involves: 129S1/Sv * 129X1/SvJ * ICR MGI:3805318


Genotype
MGI:3805316
hm1
Allelic
Composition		 Flt4tm2Ali/Flt4tm2Ali
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * ICR
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Flt4tm2Ali mutation (0 available); any Flt4 mutation (76 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging

immune system
absent lymphatic vessels ( J:137909 )
• lack lymphatic vasculature in the skin at E17.5

homeostasis/metabolism
hydrops fetalis ( J:137909 )
• appear swollen at E14.5




Genotype
MGI:3805317
ht2
Allelic
Composition		 Flt4tm2Ali/Flt4+
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * ICR
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Flt4tm2Ali mutation (0 available); any Flt4 mutation (76 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal lymph circulation ( J:137909 )
• mesenteric lymphatic vessels appear diffuse suggesting that they are leaky and dysfunctional
abnormal lymphatic vessel morphology ( J:137909 )
• only some remnants of lymphatic vessels are present in the skin at E17.5

homeostasis/metabolism
hydrops fetalis ( J:137909 )
• appear swollen at E14.5
chylous ascites ( J:137909 )
• transient accumulation of chylous ascites in the abdomen after birth

cardiovascular system
abnormal lymph circulation ( J:137909 )
• mesenteric lymphatic vessels appear diffuse suggesting that they are leaky and dysfunctional




Genotype
MGI:3805318
ht3
Allelic
Composition		 Flt4tm1Ali/Flt4tm2Ali
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * ICR
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Flt4tm1Ali mutation (1 available); any Flt4 mutation (76 available)
Flt4tm2Ali mutation (0 available); any Flt4 mutation (76 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
absent lymphatic vessels ( J:137909 )
• absence of lymphatic vessels in the skin and mesenterium at E18.5




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
06/12/2024
MGI 6.13 		The Jackson Laboratory