Phenotypes associated with this allele

• Allele Symbol: Tnks^tm1.1Yjc
• Allele Name: targeted mutation 1.1, Y Jeffrey Chiang
• Allele ID: MGI:3804704
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Tnks^tm1.1Yjc/Tnks^tm1.1Yjc	involves: 129S1/Sv * FVB/N	MGI:3806324
cx2	Tnks^tm1.1Yjc/Tnks^tm1.1Yjc Tnks2^tm1.1Yjc/Tnks2^tm1.1Yjc	involves: 129S1/Sv * FVB/N	MGI:3806325
cx3	Tnks^tm1.1Yjc/Tnks^+ Tnks2^tm1.1Yjc/Tnks2^tm1.1Yjc	involves: 129S1/Sv * FVB/N	MGI:3806326

Genotype
MGI:3806324

hm1

• Allelic Composition: Tnks^tm1.1Yjc/Tnks^tm1.1Yjc
• Genetic Background: involves: 129S1/Sv * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

cellular phenotype ( J:137985 )

N • mice exhibit normal cell cycling, irradiation sensitivity and telomere length

growth/size/body

growth/size/body region phenotype ( J:137985 )

N • unlike Tnks2 knockout mice, body weight and growth are normal

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:137985 )

N • unlike Tnks2 knockout mice, adipose glucose uptake is normal

Genotype
MGI:3806325

cx2

• Allelic Composition: Tnks^tm1.1Yjc/Tnks^tm1.1Yjc; Tnks2^tm1.1Yjc/Tnks2^tm1.1Yjc
• Genetic Background: involves: 129S1/Sv * FVB/N

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:137985 )

• mice die between E10.5 and E12.5

embryo

decreased embryo size ( J:137985 )

• at E10.5, mutant embryos are small compared to wild-type controls

abnormal placenta morphology ( J:137985 )

decreased trophoblast giant cell number ( J:137985 )

absent umbilical cord blood vessels ( J:137985 )

• at E10.5, all mutant embryos show absence of umbilical vessels

absent umbilical cord ( J:137985 )

• at E10.5, mutant embryos lack an umbilical cord

growth/size/body

decreased embryo size ( J:137985 )

• at E10.5, mutant embryos are small compared to wild-type controls

integument

pallor ( J:137985 )

• at E10.5, mutant embryos are pale compared to wild-type controls

Genotype
MGI:3806326

cx3

• Allelic Composition: Tnks^tm1.1Yjc/Tnks⁺; Tnks2^tm1.1Yjc/Tnks2^tm1.1Yjc
• Genetic Background: involves: 129S1/Sv * FVB/N

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:137985 )

• mice die between E10.5 and E12.5