Phenotypes associated with this allele

• Allele Symbol: Ppme1^tm1Crv
• Allele Name: targeted mutation 1, Benjamin J Cravatt
• Allele ID: MGI:3804708
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ppme1^tm1Crv/Ppme1^tm1Crv	involves: 129S6/SvEvTac * C57BL/6J	MGI:3804893

Genotype
MGI:3804893

hm1

• Allelic Composition: Ppme1^tm1Crv/Ppme1^tm1Crv
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:138002 )

• animals do not commence normal breathing or suckling behaviour and die during first day after birth

behavior/neurological

abnormal suckling behavior ( J:138002 )

• animals do not commence normal suckling behaviour after birth

respiratory system

abnormal breathing pattern ( J:138002 )

• animals do not commence normal breathing after birth

homeostasis/metabolism

abnormal enzyme/coenzyme activity ( J:138002 )

• phosphoprotein phosphatase 2A catalytic subunit (Ppp2ca) is not demethylated in mutant mice

• phosphoprotein phosphatase 2A catalytic subunit (Ppp2ca) activity is severely diminished