Phenotypes associated with this allele

• Allele Symbol: Fgf16^tm1Paca
• Allele Name: targeted mutation 1, Peter A Cattini
• Allele ID: MGI:3804709
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Fgf16^tm1Paca/Fgf16^tm1Paca	involves: 129S1/Sv * 129X1/SvJ * Black Swiss	MGI:3806241
ot2	Fgf16^tm1Paca/Y	involves: 129S1/Sv * 129X1/SvJ * Black Swiss	MGI:3805380

Genotype
MGI:3806241

hm1

• Allelic Composition: Fgf16^tm1Paca/Fgf16^tm1Paca
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Black Swiss

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

prenatal lethality, complete penetrance ( J:138004 )

♀ • no homozygous female embryos are born

Genotype
MGI:3805380

ot2

• Allelic Composition: Fgf16^tm1Paca/Y
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Black Swiss

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:138004 )

♂ • mice are normal up to E10.5

♂ • all hemizygous male mice die between E10.5 and E12.5

♂ • growth retarded or resorbing at E12.5

embryo

abnormal first pharyngeal arch morphology ( J:138004 )

♂ • failure of the upper pharyngeal arch to fuse to the upper mandible

embryonic growth retardation ( J:138004 )

♂ • growth retarded at E12.5

cardiovascular system

cardiovascular system phenotype ( J:138004 )

♂N • cardiac morphology normal at E9.5

abnormal heart morphology ( J:138004 )

♂

dilated heart atrium ( J:138004 )

♂ • both atrial lumina enlarged at E11.5

abnormal heart ventricle morphology ( J:138004 )

♂

trabecula carnea hypoplasia ( J:138004 )

♂ • development compromised at E10.5

♂ • poor trabeculation at E11.5, particularly in the right part of the ventricle

thin ventricular wall ( J:138004 )

♂ • at E11.5

dilated heart ventricle ( J:138004 )

♂ • dilation of common ventricle at E10.5

♂ • enlarged lumen at E11.5 in embryos still alive

internal hemorrhage ( J:138004 )

♂ • in and around the cardiac and ventral body regions

growth/size/body

embryonic growth retardation ( J:138004 )

♂ • growth retarded at E12.5

craniofacial

abnormal first pharyngeal arch morphology ( J:138004 )

♂ • failure of the upper pharyngeal arch to fuse to the upper mandible

muscle

trabecula carnea hypoplasia ( J:138004 )

♂ • development compromised at E10.5

♂ • poor trabeculation at E11.5, particularly in the right part of the ventricle