Phenotypes associated with this allele

• Allele Symbol: Tnnt2^tm1Feah
• Allele Name: targeted mutation 1, Ferhaan Ahmad
• Allele ID: MGI:3805012
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Tnnt2^tm1Feah/Tnnt2^tm1Feah	involves: 129S6/SvEvTac * FVB/N	MGI:3805037
cx2	Tg(Myh6-Tnnt2*)1Feah/0 Tnnt2^tm1Feah/Tnnt2^+	involves: 129S/SvEv * 129S6/SvEvTac * FVB/N	MGI:3805039

Genotype
MGI:3805037

hm1

• Allelic Composition: Tnnt2^tm1Feah/Tnnt2^tm1Feah
• Genetic Background: involves: 129S6/SvEvTac * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:137964 )

• mice are all dead by E11.5 to E12.5

embryonic lethality between somite formation and embryo turning, incomplete penetrance ( J:137964 )

• some mouse loss occurs prior to E9.5

cardiovascular system

abnormal myocardial fiber morphology ( J:137964 )

• organized sarcomere structures are absent

abnormal heart development ( J:137964 )

• despite normal heart looping, ventricular walls are thinner than in wild-type or heterozygous mice

pericardial effusion ( J:137964 )

decreased cardiac muscle contractility ( J:137964 )

• spontaneous or electrically-stimulated contraction is absent

embryo

embryonic growth retardation ( J:137964 )

muscle

abnormal myocardial fiber morphology ( J:137964 )

• organized sarcomere structures are absent

decreased cardiac muscle contractility ( J:137964 )

• spontaneous or electrically-stimulated contraction is absent

growth/size/body

embryonic growth retardation ( J:137964 )

homeostasis/metabolism

pericardial effusion ( J:137964 )

Genotype
MGI:3805039

cx2

• Allelic Composition: Tg(Myh6-Tnnt2*)1Feah/0; Tnnt2^tm1Feah/Tnnt2⁺
• Genetic Background: involves: 129S/SvEv * 129S6/SvEvTac * FVB/N

cardiovascular system

dilated heart ( J:137964 )

• massive

dilated cardiomyopathy ( J:137964 )

• mice exhibit severe dilated cardiomyopathy

• left ventricular end diastolic diameter is increased compared to in heterozygous mice with a wild-type transgene

decreased cardiac muscle contractility ( J:137964 )

increased heart rate ( J:137964 )

• non-sustained tachycardia was induced in 2 of 5 mice compared to only 1 of 10 wild-type mice

abnormal heart electrocardiography waveform feature ( J:137964 )

prolonged HV interval ( J:137964 )

prolonged QRS complex duration ( J:137964 )

prolonged QT interval ( J:137964 )

abnormal myocardial fiber physiology ( J:137964 )

• mice exhibit myofiber calcium desensitization

congestive heart failure ( J:137964 )

• evident by molecular markers

muscle

dilated cardiomyopathy ( J:137964 )

• mice exhibit severe dilated cardiomyopathy

• left ventricular end diastolic diameter is increased compared to in heterozygous mice with a wild-type transgene

decreased cardiac muscle contractility ( J:137964 )