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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Wnt9btm1.2Amc
targeted mutation 1.2, Andrew P McMahon
MGI:3805020
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Wnt9btm1.1Amc/Wnt9btm1.2Amc
Tg(CAG-cre/Esr1*)5Amc/0 		involves: 129X1/SvJ * C57BL/6 * CBA MGI:5428000
cn2
 		Wnt9btm1.1Amc/Wnt9btm1.2Amc
Tg(Cdh16-cre)91Igr/0 		involves: 129X1/SvJ * ICR MGI:5427999
cn3
 		Ctnnb1tm1Mmt/Ctnnb1+
Wnt9btm1.1Amc/Wnt9btm1.2Amc
Tg(Cdh16-cre)91Igr/0 		involves: 129X1/SvJ * ICR MGI:5428001


Genotype
MGI:5428000
cn1
Allelic
Composition		 Wnt9btm1.1Amc/Wnt9btm1.2Amc
Tg(CAG-cre/Esr1*)5Amc/0
Genetic
Background		 involves: 129X1/SvJ * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(CAG-cre/Esr1*)5Amc mutation (9 available)
Wnt9btm1.1Amc mutation (0 available); any Wnt9b mutation (23 available)
Wnt9btm1.2Amc mutation (1 available); any Wnt9b mutation (23 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:151498 )
• all mice treated with tamoxifen from E15.5 die by P90

renal/urinary system
kidney cyst ( J:151498 )
• in mice treated with tamoxifen from E15.5 to P10
• however, mice treated with tamoxifen after P10 do not develop cysts

growth/size/body
kidney cyst ( J:151498 )
• in mice treated with tamoxifen from E15.5 to P10
• however, mice treated with tamoxifen after P10 do not develop cysts




Genotype
MGI:5427999
cn2
Allelic
Composition		 Wnt9btm1.1Amc/Wnt9btm1.2Amc
Tg(Cdh16-cre)91Igr/0
Genetic
Background		 involves: 129X1/SvJ * ICR
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Cdh16-cre)91Igr mutation (1 available)
Wnt9btm1.1Amc mutation (0 available); any Wnt9b mutation (23 available)
Wnt9btm1.2Amc mutation (1 available); any Wnt9b mutation (23 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:151498 )
• most mice die between P30 and P45 with no mice surviving past P60

renal/urinary system
kidney cyst ( J:151498 )
• delayed compared to in Wnt9btm1Amc homozygotes
• few cysts at P1
• prevalent by P10
• by P15, mice develop cysts in all nephrons of glomerulus, proximal tubule, loop of Henle and collecting duct
abnormal kidney collecting duct epithelium morphology ( J:151498 )
• collecting duct epithelial cells exhibit randomized elongation unlike in wild-type mice
abnormal renal tubule epithelium morphology ( J:151498 )
• at P5, epithelium cell divisions are not oriented within the plane of the epithelium unlike in control mice
• by P30, little normal epithelia remains

growth/size/body
kidney cyst ( J:151498 )
• delayed compared to in Wnt9btm1Amc homozygotes
• few cysts at P1
• prevalent by P10
• by P15, mice develop cysts in all nephrons of glomerulus, proximal tubule, loop of Henle and collecting duct
renal glomerulus cyst ( J:151498 )




Genotype
MGI:5428001
cn3
Allelic
Composition		 Ctnnb1tm1Mmt/Ctnnb1+
Wnt9btm1.1Amc/Wnt9btm1.2Amc
Tg(Cdh16-cre)91Igr/0
Genetic
Background		 involves: 129X1/SvJ * ICR
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ctnnb1tm1Mmt mutation (0 available); any Ctnnb1 mutation (48 available)
Tg(Cdh16-cre)91Igr mutation (1 available)
Wnt9btm1.1Amc mutation (0 available); any Wnt9b mutation (23 available)
Wnt9btm1.2Amc mutation (1 available); any Wnt9b mutation (23 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
renal/urinary system
kidney cyst ( J:151498 )
• cystic index at P1 is increased compared to in Wnt9btm1.1Amc/Wnt9btm1.2Amc Tg(Cdh16-cre)91Igr mice

growth/size/body
kidney cyst ( J:151498 )
• cystic index at P1 is increased compared to in Wnt9btm1.1Amc/Wnt9btm1.2Amc Tg(Cdh16-cre)91Igr mice




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Send questions and comments to User Support. 		last database update
08/02/2024
MGI 6.24 		The Jackson Laboratory