All Phenotypes Tg(Myh6-Tnnt2*)1Feah MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Tg(Myh6-Tnnt2*)1Feah
transgene insertion 1, Fehaan Ahmad
MGI:3805021

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Tg(Myh6-Tnnt2*)1Feah/0 Tnnt2^tm1Feah/Tnnt2⁺	involves: 129S/SvEv * 129S6/SvEvTac * FVB/N	MGI:3805039
tg2	Tg(Myh6-Tnnt2*)1Feah/0	129S.FVB-Tg(Myh6-Tnnt2*)1Feah	MGI:3805038

Allelic Composition	Tg(Myh6-Tnnt2*)1Feah/0 Tnnt2^tm1Feah/Tnnt2⁺
Genetic Background	involves: 129S/SvEv * 129S6/SvEvTac * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Myh6-Tnnt2*)1Feah mutation (0 available)
Tnnt2^tm1Feah mutation (0 available); any Tnnt2 mutation (51 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

dilated heart ( J:137964 )

• massive

dilated cardiomyopathy ( J:137964 )

• mice exhibit severe dilated cardiomyopathy

• left ventricular end diastolic diameter is increased compared to in heterozygous mice with a wild-type transgene

decreased cardiac muscle contractility ( J:137964 )

increased heart rate ( J:137964 )

• non-sustained tachycardia was induced in 2 of 5 mice compared to only 1 of 10 wild-type mice

abnormal heart electrocardiography waveform feature ( J:137964 )

prolonged HV interval ( J:137964 )

prolonged QRS complex duration ( J:137964 )

prolonged QT interval ( J:137964 )

abnormal myocardial fiber physiology ( J:137964 )

• mice exhibit myofiber calcium desensitization

congestive heart failure ( J:137964 )

• evident by molecular markers

muscle

dilated cardiomyopathy ( J:137964 )

• mice exhibit severe dilated cardiomyopathy

• left ventricular end diastolic diameter is increased compared to in heterozygous mice with a wild-type transgene

decreased cardiac muscle contractility ( J:137964 )

Allelic Composition	Tg(Myh6-Tnnt2*)1Feah/0
Genetic Background	129S.FVB-Tg(Myh6-Tnnt2*)1Feah

Find Mice

Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

dilated cardiomyopathy ( J:137964 )

• dilated cardiomyopathy is mild at 9 weeks of age

• however, electrocardiogram telemetry, cardiac electrophysiology and heart histology are normal

muscle

dilated cardiomyopathy ( J:137964 )

• dilated cardiomyopathy is mild at 9 weeks of age

• however, electrocardiogram telemetry, cardiac electrophysiology and heart histology are normal

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