Phenotypes associated with this allele

• Allele Symbol: Gt(ROSA)26Sor^{tm1(Rybp/EGFP)Cve}
• Allele Name: targeted mutation 1, Ales Cvekel
• Allele ID: MGI:3805312
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Gt(ROSA)26Sor^tm1(Rybp/EGFP)Cve/Gt(ROSA)26Sor^+ Tg(Cryaa-cre)10Mlr/0	involves: 129S1/Sv * 129X1/SvJ	MGI:3805333
cn2	Gt(ROSA)26Sor^tm1(Rybp/EGFP)Cve/Gt(ROSA)26Sor^tm1(Rybp/EGFP)Cve Tmem163^Tg(ACTB-cre)2Mrt/0	involves: 129S1/Sv * 129X1/SvJ * FVB/N	MGI:3805335
cn3	Gt(ROSA)26Sor^tm1(Rybp/EGFP)Cve/Gt(ROSA)26Sor^+ Tmem163^Tg(ACTB-cre)2Mrt/0	involves: 129S1/Sv * 129X1/SvJ * FVB/N	MGI:3805336

Genotype
MGI:3805333

cn1

• Allelic Composition: Gt(ROSA)26Sor^{tm1(Rybp/EGFP)Cve}/Gt(ROSA)26Sor⁺; Tg(Cryaa-cre)10Mlr/0
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

vision/eye

abnormal lens fiber morphology ( J:134428 )

• lens from 2 day old mice exhibit cortical inhomogenicity

• lens fiber mass decreases with age

cataract ( J:134428 )

• cataracts develop in adult mice due to loss of lens fiber cells

Genotype
MGI:3805335

cn2

• Allelic Composition: Gt(ROSA)26Sor^{tm1(Rybp/EGFP)Cve}/Gt(ROSA)26Sor^{tm1(Rybp/EGFP)Cve}; Tmem163^{Tg(ACTB-cre)2Mrt}/0
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N

vision/eye

cornea vascularization ( J:134428 )

• 80% of lens in adult mice have neo-vascularization with first signs of blood vessel development visible in the stroma of the cornea by the first week of age

• electron microscopy reveals that capillaries are present at birth

absent eye anterior chamber ( J:134428 )

• absence of the anterior chamber occurs in some mice by one week of age

cataract ( J:134428 )

• cataracts occur in some mice by adulthood

coloboma ( J:134428 )

• occurs in some mice by the first week of age

retina fold ( J:134428 )

• folding of the retina occurs in some mice

abnormal vitreous body morphology ( J:134428 )

• the vitreous body is absent in some mice by one week of age

cardiovascular system

cornea vascularization ( J:134428 )

• 80% of lens in adult mice have neo-vascularization with first signs of blood vessel development visible in the stroma of the cornea by the first week of age

• electron microscopy reveals that capillaries are present at birth

Genotype
MGI:3805336

cn3

• Allelic Composition: Gt(ROSA)26Sor^{tm1(Rybp/EGFP)Cve}/Gt(ROSA)26Sor⁺; Tmem163^{Tg(ACTB-cre)2Mrt}/0
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N

vision/eye

cornea vascularization ( J:134428 )

• 35% of lens in adult mice have neo-vascularization with first signs of blood vessel development visible by the first week of age

cardiovascular system

cornea vascularization ( J:134428 )

• 35% of lens in adult mice have neo-vascularization with first signs of blood vessel development visible by the first week of age