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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Gata2tm2(Gata2)Jeng
targeted mutation 2, James Douglas Engel
MGI:3805382
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Gata2tm2(Gata2)Jeng/Gata2tm2(Gata2)Jeng involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * DBA MGI:3805456


Genotype
MGI:3805456
hm1
Allelic
Composition
Gata2tm2(Gata2)Jeng/Gata2tm2(Gata2)Jeng
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * DBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gata2tm2(Gata2)Jeng mutation (0 available); any Gata2 mutation (30 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• only 30% of mice survive beyond 1 month of age
• mice begin to die at E17.5 with 50% of mice dieing by day 2 and survival decreasing over the next 4 weeks
• mice begin to die at E17.5 with 50% of mice dying by day 2 and survival decreasing over the next 4 weeks
• mice begin to die at E17.5 with 50% of mice dying by day 2 and survival decreasing over the next 4 weeks
• mice begin to die at E17.5 with 50% of mice dying by day 2 and survival decreasing over the next 4 weeks
• only 30% of mice survive beyond 1 month of age

renal/urinary system
• 57% of mice exhibit urological abnormalities
• renal parenchyma is thinner than in wild-type mice
• in some mice
• in some mice
• 57% of mice exhibit uropathy
• in 50% of mice ureteral budding occurs more anterior along the Wolffian duct than in wild-type mice
• mice frequently exhibit uni- or bi-lateral megaureter

growth/size/body





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last database update
10/29/2024
MGI 6.24
The Jackson Laboratory