mortality/aging
• only 30% of mice survive beyond 1 month of age
|
• mice begin to die at E17.5 with 50% of mice dieing by day 2 and survival decreasing over the next 4 weeks
|
• mice begin to die at E17.5 with 50% of mice dying by day 2 and survival decreasing over the next 4 weeks
|
• mice begin to die at E17.5 with 50% of mice dying by day 2 and survival decreasing over the next 4 weeks
|
• mice begin to die at E17.5 with 50% of mice dying by day 2 and survival decreasing over the next 4 weeks
• only 30% of mice survive beyond 1 month of age
|
renal/urinary system
• 57% of mice exhibit urological abnormalities
|
• renal parenchyma is thinner than in wild-type mice
|
• in some mice
|
• in some mice
|
• 57% of mice exhibit uropathy
|
• in 50% of mice ureteral budding occurs more anterior along the Wolffian duct than in wild-type mice
|
large ureter
(
J:138257
)
• mice frequently exhibit uni- or bi-lateral megaureter
|
growth/size/body