Phenotypes associated with this allele

• Allele Symbol: Foxq1^tm1Wen
• Allele Name: targeted mutation 1, Wolfgang Engel
• Allele ID: MGI:3805482
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Foxq1^tm1Wen/Foxq1^tm1Wen	involves: 129S1/Sv * 129X1/SvJ * C57BL/6J	MGI:3805509

Genotype
MGI:3805509

hm1

• Allelic Composition: Foxq1^tm1Wen/Foxq1^tm1Wen
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

lethality throughout fetal growth and development, incomplete penetrance ( J:138249 )

• nearly half of all mice die between E10.5 and E15.5

embryonic lethality during organogenesis, incomplete penetrance ( J:138249 )

• nearly half of all mice die between E10.5 and E15.5

digestive/alimentary system

decreased digestive secretion ( J:138249 )

• following treatment with histamine or gastrin, mice fail to exhibit an increase in acid secretion in the stomach unlike wild-type mice

• stomach parietal cells do not form apical secretory canaliculi as in wild-type mice when stimulated with gastrin

nervous system

abnormal brain development ( J:138249 )

• at E10.5, mice exhibit shrinkage of the brain vesicle

homeostasis/metabolism

abnormal response/metabolism to endogenous compounds ( J:138249 )

• stomach parietal cells do not form apical secretory canaliculi as in wild-type mice when stimulated with gastrin

integument

shiny fur ( J:138249 )

• mice have satiny hair

growth/size/body

abnormal head morphology ( J:138249 )

• at E10.5, mice have abnormal head morphology due to shrinkage of the brain vesicle