Phenotypes associated with this allele

• Allele Symbol: Cul4a/Pcid2^tm2Ktc
• Allele Name: targeted mutation 2, Kristin T Chun
• Allele ID: MGI:3805522
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Cul4a/Pcid2^tm2Ktc/Cul4a/Pcid2^tm2Ktc Tg(Mx1-cre)1Cgn/0	involves: 129S/SvEv * C57BL/6 * CBA * FVB/N	MGI:3805575

Genotype
MGI:3805575

cn1

• Allelic Composition: Cul4a/Pcid2^tm2Ktc/Cul4a/Pcid2^tm2Ktc; Tg(Mx1-cre)1Cgn/0
• Genetic Background: involves: 129S/SvEv * C57BL/6 * CBA * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:138468 )

• mice die within 10 days following induction with pIpC

• cells induced with pIpC, when transplanted into irradiated wild-type mice, causes a lethal failure of hematopoiesis

hematopoietic system

small thymus ( J:138468 )

• presumably due to spontaneous production of interferon in induced and un-induced mice

abnormal definitive hematopoiesis ( J:138468 )

impaired hematopoiesis ( J:138468 )

• following induction with pIpC, blood counts of mature hematopoietic cells is reduced

• cells induced with pIpC, when transplanted into irradiated wild-type mice, causes a lethal failure of hematopoiesis

decreased bone marrow cell number ( J:138468 )

• 4 days following induction with pIpC, bone marrow cellularity is reduced 10-fold due to 4.5-fold increase in apoptosis and decreased proliferation

decreased hematocrit ( J:138468 )

• in the one mouse that survived 10 days following induction with pIpC

thrombocytopenia ( J:138468 )

• in the one mouse that survived 10 days following induction with pIpC

decreased hematopoietic stem cell number ( J:138468 )

• following induction with pIpC, hematopoietic progenitor cells are not detected

abnormal leukocyte morphology ( J:138468 )

decreased neutrophil cell number ( J:138468 )

• following induction with pIpC, the neutrophil count is reduced to near zero by day 4

decreased lymphocyte cell number ( J:138468 )

• following induction with pIpC, lymphocyte counts decrease to a greater extent than in similarly treated mice without the cre transgene and do not recover

decreased monocyte cell number ( J:138468 )

• following induction with pIpC, monocyte counts decrease to a greater extent than in similarly treated mice without the cre transgene and do not recover

abnormal spleen morphology ( J:138468 )

abnormal spleen capsule morphology ( J:138468 )

• irregular following induction with pIpC

decreased spleen red pulp amount ( J:138468 )

• following induction with pIpC, red pulp size is reduced with a marked loss of hematopoietic cells

decreased spleen weight ( J:138468 )

• following induction with pIpC

spleen hypoplasia ( J:138468 )

• following induction with pIpC, spleen cellularity is reduced 2-fold

decreased spleen white pulp amount ( J:138468 )

• following induction with pIpC, white pulp is moderately reduced with increased apoptosis of lymphocytes compared to in mice without the cre transgene

digestive/alimentary system

increased enterocyte apoptosis ( J:138468 )

• following induction with pIpC, mice exhibit an increase in the number of apoptotic enterocytes at the base and along the crypts

abnormal enterocyte morphology ( J:138468 )

• following induction with pIpC, enterocytes are hyperchromatic with enlarged nuclei and loss of polarity

• following induction with pIpC, villus enterocytes are swollen with vacuolated cytoplasm and small pycnotic nuclei

abnormal small intestine crypts of Lieberkuhn morphology ( J:138468 )

• following induction with pIpC, scattered crypts are diluted with necrotic cellular debris and lined by flattened epithelial cells

small intestinal villus atrophy ( J:138468 )

• following induction with pIpC, mice exhibit villus atrophy with an increase in the number of apoptotic enterocytes at the base and along the crypts

immune system

small thymus ( J:138468 )

• presumably due to spontaneous production of interferon in induced and un-induced mice

abnormal leukocyte morphology ( J:138468 )

decreased neutrophil cell number ( J:138468 )

• following induction with pIpC, the neutrophil count is reduced to near zero by day 4

decreased lymphocyte cell number ( J:138468 )

• following induction with pIpC, lymphocyte counts decrease to a greater extent than in similarly treated mice without the cre transgene and do not recover

decreased monocyte cell number ( J:138468 )

• following induction with pIpC, monocyte counts decrease to a greater extent than in similarly treated mice without the cre transgene and do not recover

abnormal spleen morphology ( J:138468 )

abnormal spleen capsule morphology ( J:138468 )

• irregular following induction with pIpC

decreased spleen red pulp amount ( J:138468 )

• following induction with pIpC, red pulp size is reduced with a marked loss of hematopoietic cells

decreased spleen weight ( J:138468 )

• following induction with pIpC

spleen hypoplasia ( J:138468 )

• following induction with pIpC, spleen cellularity is reduced 2-fold

decreased spleen white pulp amount ( J:138468 )

• following induction with pIpC, white pulp is moderately reduced with increased apoptosis of lymphocytes compared to in mice without the cre transgene

endocrine/exocrine glands

abnormal small intestine crypts of Lieberkuhn morphology ( J:138468 )

• following induction with pIpC, scattered crypts are diluted with necrotic cellular debris and lined by flattened epithelial cells

small thymus ( J:138468 )

• presumably due to spontaneous production of interferon in induced and un-induced mice

cellular

increased enterocyte apoptosis ( J:138468 )

• following induction with pIpC, mice exhibit an increase in the number of apoptotic enterocytes at the base and along the crypts