Phenotypes associated with this allele

• Allele Symbol: Fzr1^{Gt(RRJ067)Byg}
• Allele Name: gene trap RRJ067, BayGenomics
• Allele ID: MGI:3805590
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Fzr1^Gt(RRJ067)Byg/Fzr1^Gt(RRJ067)Byg	involves: 129P2/OlaHsd	MGI:3806021
ht2	Fzr1^Gt(RRJ067)Byg/Fzr1^+	involves: 129P2/OlaHsd	MGI:3806023

Genotype
MGI:3806021

hm1

• Allelic Composition: Fzr1^{Gt(RRJ067)Byg}/Fzr1^{Gt(RRJ067)Byg}
• Genetic Background: involves: 129P2/OlaHsd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:138545 )

• no embryos survive beyond E9.5

growth/size/body

embryonic growth retardation ( J:138545 )

• developmentally delayed by about 1 day at E9.5

decreased embryo size ( J:138545 )

• much smaller in size at E9.5 than controls

embryo

embryonic growth retardation ( J:138545 )

• developmentally delayed by about 1 day at E9.5

decreased embryo size ( J:138545 )

• much smaller in size at E9.5 than controls

abnormal placenta morphology ( J:138545 )

absent trophoblast giant cells ( J:138545 )

small placenta ( J:138545 )

• smaller and thinner than controls at E9.5

cellular

binucleate ( J:138545 )

• about 12% of MEFs in culture are binucleate

abnormal mitosis ( J:138545 )

• small increase in the number of telophase cells

• mitosis is otherwise normal

decreased cell proliferation ( J:138545 )

• MEF growth is slower in culture

• MEF growth in culture ceases after passage 6

Genotype
MGI:3806023

ht2

• Allelic Composition: Fzr1^{Gt(RRJ067)Byg}/Fzr1⁺
• Genetic Background: involves: 129P2/OlaHsd

nervous system

reduced long-term potentiation ( J:138545 )

• late long term potentiation evoked by multiple high frequency stimulation strings is impaired

• decays to baseline within 3 hours whereas it persists beyond three hours in controls

behavior/neurological

behavior/neurological phenotype ( J:138545 )

N • normal performance in cued (auditory) fear conditioning tests

abnormal contextual conditioning behavior ( J:138545 )

• poor performance in contextual fear conditioning