Phenotypes associated with this allele

• Allele Symbol: Eppk1^tm1Gwi
• Allele Name: targeted mutation 1, Gerhard Wiche
• Allele ID: MGI:3805682
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Eppk1^tm1Gwi/Eppk1^tm1Gwi	involves: 129P2/OlaHsd	MGI:3805687
hm2	Eppk1^tm1Gwi/Eppk1^tm1Gwi	involves: 129P2/OlaHsd * C57BL/6	MGI:3805685

Genotype
MGI:3805687

hm1

• Allelic Composition: Eppk1^tm1Gwi/Eppk1^tm1Gwi
• Genetic Background: involves: 129P2/OlaHsd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

integument

abnormal keratinocyte physiology ( J:138481 )

• keratin filament disruption caused by serine/threonine (okadaic acid) and tyrosine (orthovanadate) phosphatase inhibitors proceeds faster in mutant cultured keratinocytes than in controls

• 46% of differentiated keratinocytes in culture exhibit keratin filament disruption within two hours of okadaic acid treatment compared to under 10% for controls

• a significantly higher percentage of keratinocytes without intact keratin filament networks is found within 3 minutes of orthovanadate incubation

Genotype
MGI:3805685

hm2

• Allelic Composition: Eppk1^tm1Gwi/Eppk1^tm1Gwi
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

normal phenotype

no abnormal phenotype detected ( J:138604 )

• mice are viable, fertile, and had no detectable abnormalities in the skin