Phenotypes associated with this allele

• Allele Symbol: Tg(Prnp-SNCA)7Vle
• Allele Name: transgene insertion 7, Virginia M-Y Lee
• Allele ID: MGI:3805701
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Snca^tm1Rosl/Snca^tm1Rosl Tg(Prnp-SNCA)7Vle/Tg(Prnp-SNCA)7Vle	involves: 129X1/SvJ * C3H * C57BL/6	MGI:3805760

Genotype
MGI:3805760

cx1

• Allelic Composition: Snca^tm1Rosl/Snca^tm1Rosl; Tg(Prnp-SNCA)7Vle/Tg(Prnp-SNCA)7Vle
• Genetic Background: involves: 129X1/SvJ * C3H * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

astrocytosis ( J:138194 )

• following injection of LPS into the substantia nigra

loss of dopaminergic neurons ( J:138194 )

• following injection of LPS into the substantia nigra, mice exhibit an increased loss of dopaminergic neurons that is associated with insoluble and aggregated SNCA compared to in Snca^tm1Rosl homozygotes

• following culture with LPS, dopaminergic neurons loss is increased compared to in cultures from Snca^tm1Rosl homozygotes

• loss of dopamine neurons following injection of LPS into the substantia nigra is mediated by microglial-derived nitric oxide and superoxideloss of dopamine neurons following injection of LPS into the substantia nigra is mediated by microglial-derived nitric oxide and superoxide

• however, loss of dopamine neurons is not due to an abnormal inflammatory response following injection of LPS into the substantia nigra

immune system

abnormal response to infection ( J:138194 )

• following injection of LPS into the substantia nigra, mice exhibit a decreased loss of dopaminergic neurons compared to in Snca^tm1Rosl Tg(Prnp-SNCA*A53T)83Vle homozygotes but increased relative to in Snca^tm1Rosl homozygotes