All Phenotypes Bmi1<tm1(cre/ERT)Mrc> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Bmi1^{tm1(cre/ERT)Mrc}
targeted mutation 1, Mario R Capecchi
MGI:3805814

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Bmi1^{tm1(cre/ERT)Mrc}/Bmi1⁺ Gt(ROSA)26Sor^tm1(DTA)Mrc/Gt(ROSA)26Sor⁺	involves: 129S1/Sv * 129X1/SvJ	MGI:3805820
cn2	Bmi1^{tm1(cre/ERT)Mrc}/Bmi1⁺ Ctnnb1^tm1Mmt/Ctnnb1⁺	involves: 129S1/Sv * 129X1/SvJ	MGI:3805821
cn3	Gt(ROSA)26Sor^{tm4(EWSR1/ATF1)Mrc}/Gt(ROSA)26Sor⁺ Bmi1^{tm1(cre/ERT)Mrc}/Bmi1⁺	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:5495321

Allelic Composition	Bmi1^{tm1(cre/ERT)Mrc}/Bmi1⁺ Gt(ROSA)26Sor^tm1(DTA)Mrc/Gt(ROSA)26Sor⁺
Genetic Background	involves: 129S1/Sv * 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bmi1^{tm1(cre/ERT)Mrc} mutation (2 available); any Bmi1 mutation (31 available)
Gt(ROSA)26Sor^tm1(DTA)Mrc mutation (1 available); any Gt(ROSA)26Sor mutation (968 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:138364 )

• mice die 2 to 3 days following administration of tamoxifen for three consecutive days after weaning

digestive/alimentary system

abnormal duodenum crypts of Lieberkuhn morphology ( J:138364 )

• following administration of one dose of tamoxifen after weaning, mice exhibit areas of the duodenum that are devoid of crypt cells

• however, crypt cells recover by 9 months of age

abnormal jejunum crypts of Lieberkuhn morphology ( J:138364 )

• following administration of one dose of tamoxifen after weaning, mice exhibit areas of the jejunum that are devoid of crypt cells

• however, crypt cells recover by 9 months of age

growth/size/body

slow postnatal weight gain ( J:138364 )

• following administration of one dose of tamoxifen after weaning

• however, normal weight is recovered by 9 months of age

endocrine/exocrine glands

abnormal duodenum crypts of Lieberkuhn morphology ( J:138364 )

• following administration of one dose of tamoxifen after weaning, mice exhibit areas of the duodenum that are devoid of crypt cells

• however, crypt cells recover by 9 months of age

abnormal jejunum crypts of Lieberkuhn morphology ( J:138364 )

• following administration of one dose of tamoxifen after weaning, mice exhibit areas of the jejunum that are devoid of crypt cells

• however, crypt cells recover by 9 months of age

Allelic Composition	Bmi1^{tm1(cre/ERT)Mrc}/Bmi1⁺ Ctnnb1^tm1Mmt/Ctnnb1⁺
Genetic Background	involves: 129S1/Sv * 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bmi1^{tm1(cre/ERT)Mrc} mutation (2 available); any Bmi1 mutation (31 available)
Ctnnb1^tm1Mmt mutation (0 available); any Ctnnb1 mutation (48 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:138364 )

• mice die 50 days following administration of tamoxifen

neoplasm

increased intestinal adenoma incidence ( J:138364 )

• beginning 22 days following administration of tamoxifen

digestive/alimentary system

abnormal crypts of Lieberkuhn morphology ( J:138364 )

• the number of proliferating cells within crypts is increased 15 days following administration of tamoxifen

increased intestinal adenoma incidence ( J:138364 )

• beginning 22 days following administration of tamoxifen

endocrine/exocrine glands

abnormal crypts of Lieberkuhn morphology ( J:138364 )

• the number of proliferating cells within crypts is increased 15 days following administration of tamoxifen

Allelic Composition	Gt(ROSA)26Sor^{tm4(EWSR1/ATF1)Mrc}/Gt(ROSA)26Sor⁺ Bmi1^{tm1(cre/ERT)Mrc}/Bmi1⁺
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bmi1^{tm1(cre/ERT)Mrc} mutation (2 available); any Bmi1 mutation (31 available)
Gt(ROSA)26Sor^{tm4(EWSR1/ATF1)Mrc} mutation (0 available); any Gt(ROSA)26Sor mutation (968 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased tumor incidence ( J:194308 )

• fully penetrant tumorigenesis when tamoxifen is injected after 3 weeks of age

• tumors in deep mesenchymal tissues of the limbs and trunk

• most tumors form adjacent to bone but some are totally in muscle

• all tumors with "clear cell" morphology

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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