Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lattm6.1(HBEGF/EGFP)Mal mutation
(1 available);
any
Lat mutation
(10 available)
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immune system
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• CD4+ T cells were first transfected with a cre recombinase vector and then treated with dipthera toxin so that surviving T cells do not produce LAT protein
• when activated and transferred into T cell deficient hosts, these T cells cause splenomegaly, lymphadenopathy and secrete high levels of IL-4
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• CD4+ T cells were first transfected with a cre recombinase vector and then treated with dipthera toxin so that surviving T cells did not produce LAT protein
• these T cells show almost no intracellular calcium mobilization and no ERK -1 and -2 activation after TCR engagement
• T cells also fail to produce IFN-gamma after activation
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• CD4+ T cells transfected with a cre recombinase vector and treated with dipthera toxin do not produce IFN-gamma upon activation
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hematopoietic system
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• CD4+ T cells were first transfected with a cre recombinase vector and then treated with dipthera toxin so that surviving T cells do not produce LAT protein
• when activated and transferred into T cell deficient hosts, these T cells cause splenomegaly, lymphadenopathy and secrete high levels of IL-4
|
|
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• CD4+ T cells were first transfected with a cre recombinase vector and then treated with dipthera toxin so that surviving T cells did not produce LAT protein
• these T cells show almost no intracellular calcium mobilization and no ERK -1 and -2 activation after TCR engagement
• T cells also fail to produce IFN-gamma after activation
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|
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lattm4.1Mal mutation
(0 available);
any
Lat mutation
(10 available)
Lattm6.1(HBEGF/EGFP)Mal mutation
(1 available);
any
Lat mutation
(10 available)
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|
|
immune system
|
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• CD4+ T cells were first transfected with a cre recombinase vector and then treated with dipthera toxin so that surviving T cells only expressed the mutant Lattm1Mal allele
• when activated and transferred into T cell deficient hosts, these T cells cause splenomegaly, lymphadenopathy and secrete high levels of IL-4
• these abnormal T cells promote B cell activation in their hosts leading to high levels of IgG1 and IgE
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hematopoietic system
|
|
• CD4+ T cells were first transfected with a cre recombinase vector and then treated with dipthera toxin so that surviving T cells only expressed the mutant Lattm1Mal allele
• when activated and transferred into T cell deficient hosts, these T cells cause splenomegaly, lymphadenopathy and secrete high levels of IL-4
• these abnormal T cells promote B cell activation in their hosts leading to high levels of IgG1 and IgE
|
|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lattm1.1Mal mutation
(0 available);
any
Lat mutation
(10 available)
Lattm6.1(HBEGF/EGFP)Mal mutation
(1 available);
any
Lat mutation
(10 available)
|
|
|
immune system
|
|
• CD4+ T cells were first transfected with a cre recombinase vector and then treated with dipthera toxin so that surviving T cells only expressed the mutant Lattm1Mal allele
• when activated and transferred into T cell deficient hosts, these T cells cause splenomegaly, lymphadenopathy and secrete high levels of IL-4
• these abnormal T cells promote B cell activation in their hosts leading to high levels of IgG1 and IgE
• T cells are not pathogenic when transferred into MHC-II deficient hosts or in the absence of CD28 signalling
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hematopoietic system
|
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• CD4+ T cells were first transfected with a cre recombinase vector and then treated with dipthera toxin so that surviving T cells only expressed the mutant Lattm1Mal allele
• when activated and transferred into T cell deficient hosts, these T cells cause splenomegaly, lymphadenopathy and secrete high levels of IL-4
• these abnormal T cells promote B cell activation in their hosts leading to high levels of IgG1 and IgE
• T cells are not pathogenic when transferred into MHC-II deficient hosts or in the absence of CD28 signalling
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immune system
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• T cells from this mouse strain have a high affinity for male H-Y antigen and are sensitive to diphtheria toxin
• approximately 90% depletion of these T cells occurs upon diphtheria toxin injection into a host mouse strain carrying these cells
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hematopoietic system
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• T cells from this mouse strain have a high affinity for male H-Y antigen and are sensitive to diphtheria toxin
• approximately 90% depletion of these T cells occurs upon diphtheria toxin injection into a host mouse strain carrying these cells
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Analysis Tools