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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Pik3cbtm1Jjz
targeted mutation 1, Jean Zhao
MGI:3805847
Summary 4 genotypes


Genotype
MGI:3805860
cn1
Allelic
Composition		 Pik3cbtm1Jjz/Pik3cbtm1Jjz
Genetic
Background		 involves: 129 * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pik3cbtm1Jjz mutation (1 available); any Pik3cb mutation (152 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
increased circulating leptin level ( J:138565 )
• following administration of an adenoviral cre
impaired glucose tolerance ( J:138565 )
• following administration of an adenoviral cre
insulin resistance ( J:138565 )
• following administration of an adenoviral cre

cellular
abnormal cell physiology ( J:138565 )
• following cre-mediated recombination, mouse embryonic fibroblasts (MEFs) fail to undergo immortalization upon exposure to HRas-G12V or EGFR-Del from feeder cells
decreased fibroblast proliferation ( J:138565 )
• following cre-mediated recombination, mouse embryonic fibroblasts (MEFs) proliferate slower than wild-type MEFs




Genotype
MGI:5506907
cn2
Allelic
Composition		 Pik3catm1Jjz/Pik3catm1Jjz
Pik3cbtm1Jjz/Pik3cbtm1Jjz
Ptentm1Hwu/Ptentm1Hwu
Tg(KRT14-cre)#Smr/0
Genetic
Background		 FVB.Cg-Pik3catm1Jjz Pik3cbtm1Jjz Ptentm1Hwu Tg(KRT14-cre)#Smr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pik3catm1Jjz mutation (1 available); any Pik3ca mutation (66 available)
Pik3cbtm1Jjz mutation (1 available); any Pik3cb mutation (152 available)
Ptentm1Hwu mutation (16 available); any Pten mutation (88 available)
Tg(KRT14-cre)#Smr mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
integument
integument phenotype ( J:199362 )
N
• mutants do not develop hamartomas over a period of 300 days and epidermal thickness is normal at 8 weeks of age




Genotype
MGI:5506906
cn3
Allelic
Composition		 Pik3cbtm1Jjz/Pik3cbtm1Jjz
Ptentm1Hwu/Ptentm1Hwu
Tg(KRT14-cre)#Smr/0
Genetic
Background		 FVB.Cg-Pik3cbtm1Jjz Ptentm1Hwu Tg(KRT14-cre)#Smr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pik3cbtm1Jjz mutation (1 available); any Pik3cb mutation (152 available)
Ptentm1Hwu mutation (16 available); any Pten mutation (88 available)
Tg(KRT14-cre)#Smr mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
integument
abnormal epidermis suprabasal layer morphology ( J:199362 )
• accumulation of terminally differentiated suprabasal cells
skin lesions ( J:199362 )
• development of skin lesions is delayed and severity is reduced compared to single Pten mutants
thick skin ( J:199362 )
• skin is thickened at 8 weeks of age, but to a lesser extent than in single Pten mutants
increased skin hamartoma incidence ( J:199362 )
• develop skin hamartomas with a median latency of 131 days

neoplasm
increased skin hamartoma incidence ( J:199362 )
• develop skin hamartomas with a median latency of 131 days




Genotype
MGI:3805861
cn4
Allelic
Composition		 Pik3cbtm1Jjz/Pik3cbtm1Jjz
Tg(Pbsn-cre)4Prb/0
Genetic
Background		 involves: 129 * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pik3cbtm1Jjz mutation (1 available); any Pik3cb mutation (152 available)
Tg(Pbsn-cre)4Prb mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
neoplasm ( J:138565 )
N
• unlike in Pten null mice, tumorigenesis in the prostate is not detected




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory