Phenotypes associated with this allele

• Allele Symbol: Smad1^tm1Tako
• Allele Name: targeted mutation 1, Takashi Kobayashi
• Allele ID: MGI:3805956
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Smad1^tm1Tako/Smad1^tm1Tako	involves: 129/Sv * 129P2/OlaHsd * C57BL/6 * DBA/2	MGI:3805987

Genotype
MGI:3805987

hm1

• Allelic Composition: Smad1^tm1Tako/Smad1^tm1Tako
• Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6 * DBA/2

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:79513 )

• mice die between E10.5 and E11.5 of abnormality in mesenchymal tissues

reproductive system

decreased primordial germ cell number ( J:79513 )

• at somite stage, 2 of 21 mice have a few primordial germ cells whereas the remaining mice have none

absent primordial germ cells ( J:79513 )

• no primordial germ cells are detected at E7.5 and by early somite stage 19 of 21 mice have no detectable primordial germ cells

embryo

abnormal mesenchyme morphology ( J:79513 )

• despite normal development and differentiation of mesoderm, mice die between E10.5 and E11.5 of abnormality in mesenchymal tissues

delayed allantois development ( J:79513 )

• mice exhibit a delay in allantois development

• Background Sensitivity: mice exhibit a more severe delay in allantois development when further backcrossed onto a C57BL/6 background

cellular

decreased primordial germ cell number ( J:79513 )

• at somite stage, 2 of 21 mice have a few primordial germ cells whereas the remaining mice have none

absent primordial germ cells ( J:79513 )

• no primordial germ cells are detected at E7.5 and by early somite stage 19 of 21 mice have no detectable primordial germ cells