Phenotypes associated with this allele

• Allele Symbol: Tg(H2-L-IL6)1Kish
• Allele Name: transgene insertion 1, Tadamitsu Kishimoto
• Allele ID: MGI:3806003
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
tg1	Tg(H2-L-IL6)1Kish/Tg(H2-L-IL6)1Kish	C57BL/6-Tg(H2-L-IL6)1Kish	MGI:3806449

Genotype
MGI:3806449

tg1

• Allelic Composition: Tg(H2-L-IL6)1Kish/Tg(H2-L-IL6)1Kish
• Genetic Background: C57BL/6-Tg(H2-L-IL6)1Kish

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

enlarged spleen ( J:128016 , J:138762 )

• by 3-4 months of age (J:138762)

abnormal definitive hematopoiesis ( J:128016 )

• treatment with an anti-IL6R antibody, MR16-1, prevents the increase in serum IgG1 levels and the development of splenomegaly and suppresses hematological abnormalities, blood chemistry abnormalities and glomerulonephritis

abnormal myelopoiesis ( J:128016 )

• mild increase in immature myeloid cells in the bone marrow

anemia ( J:128016 )

• anemia becomes severe with age

abnormal bone marrow cell morphology/development ( J:128016 )

• bone marrow shows an increase in Gr-1 positive cells

• increase in neutrophils and mild increase in immature myeloid cells and megakaryocytes in the bone marrow

• erythrobast islets are severely decreased in the bone marrow

increased megakaryocyte cell number ( J:128016 )

• mild increase in megakaryocytes in the bone marrow

decreased erythrocyte cell number ( J:128016 )

decreased hemoglobin content ( J:128016 )

increased neutrophil cell number ( J:128016 )

• increase in peripheral blood neutrophils

• increase in neutrophils in the bone marrow

thrombocytosis ( J:128016 )

• platelet counts are increased by 10 weeks of age but then subsequently undergo a decrease

increased plasma cell number ( J:128016 , J:138762 )

• large number of plasma cells in the spleen and lymph nodes (J:128016)

• plasma cell infiltration in liver and kidney (J:128016)

increased monocyte cell number ( J:128016 )

• increase in peripheral blood monocytes

increased IgG1 level ( J:128016 )

• more than 100-fold increase in IgG1 levels with aging

immune system

enlarged spleen ( J:128016 , J:138762 )

• by 3-4 months of age (J:138762)

abnormal myelopoiesis ( J:128016 )

• mild increase in immature myeloid cells in the bone marrow

increased neutrophil cell number ( J:128016 )

• increase in peripheral blood neutrophils

• increase in neutrophils in the bone marrow

increased plasma cell number ( J:128016 , J:138762 )

• large number of plasma cells in the spleen and lymph nodes (J:128016)

• plasma cell infiltration in liver and kidney (J:128016)

increased monocyte cell number ( J:128016 )

• increase in peripheral blood monocytes

increased IgG1 level ( J:128016 )

• more than 100-fold increase in IgG1 levels with aging

enlarged lymph nodes ( J:128016 , J:138762 )

• by 3-4 months of age, mice show a 10-fold increase in lymph node size due to accumulation of plasma cells (J:138762)

glomerulonephritis ( J:128016 , J:138762 )

• some mice develop mesangial proliferative glomerulonephritis (J:128016)

• by 3-4 months of age (J:138762)

neoplasm

increased plasmacytoma incidence ( J:138762 )

renal/urinary system

increased urine protein level ( J:128016 )

• 71.4% of mice develop proteinuria at 18 weeks of age

glomerulonephritis ( J:128016 , J:138762 )

• some mice develop mesangial proliferative glomerulonephritis (J:128016)

• by 3-4 months of age (J:138762)

skeleton

decreased osteoblast cell number ( J:128016 )

• disappearance of cuboidal osteoblasts in bone

abnormal trabecular bone morphology ( J:128016 )

• suppression of primary spongiosa formation

homeostasis/metabolism

decreased circulating glucose level ( J:128016 )

decreased circulating triglyceride level ( J:128016 )

decreased circulating alkaline phosphatase level ( J:128016 )

decreased circulating serum albumin level ( J:128016 )

increased circulating total protein level ( J:128016 )

increased urine protein level ( J:128016 )

• 71.4% of mice develop proteinuria at 18 weeks of age

growth/size/body

enlarged spleen ( J:128016 , J:138762 )

• by 3-4 months of age (J:138762)