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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Padi6tm1.1Jgo
targeted mutation 1.1, Jan A Gossen
MGI:3806009
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Padi6tm1.1Jgo/Padi6tm1.1Jgo involves: BALB/cJ MGI:3806014
hm2
 		Padi6tm1.1Jgo/Padi6tm1.1Jgo Not Specified MGI:3806019


Genotype
MGI:3806014
hm1
Allelic
Composition		 Padi6tm1.1Jgo/Padi6tm1.1Jgo
Genetic
Background		 involves: BALB/cJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Padi6tm1.1Jgo mutation (0 available); any Padi6 mutation (32 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
reproductive system phenotype ( J:138684 )
N
• despite female infertility, mice exhibit normal oocyte growth, maturation and ovulation and follicle development and maturation
abnormal oocyte morphology ( J:138684 )
• unlike in wild-type oocytes, cytoplasmic sheets are absent from metaphase II arrested oocytes

embryo
failure of zygotic cell division ( J:138684 )
• fertilized eggs from homozygote mothers fail to progress beyond the two cell stage

cellular
abnormal oocyte morphology ( J:138684 )
• unlike in wild-type oocytes, cytoplasmic sheets are absent from metaphase II arrested oocytes




Genotype
MGI:3806019
hm2
Allelic
Composition		 Padi6tm1.1Jgo/Padi6tm1.1Jgo
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Padi6tm1.1Jgo mutation (0 available); any Padi6 mutation (32 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
abnormal oocyte morphology ( J:138573 )
• oocytes lack cytoplasmic lattice and intermediate structures found in wild-type oocyte
• oocytes exhibit increased ribosome solubility compared to in wild-type oocytes

embryo
abnormal embryo development ( J:138573 )
• de novo protein synthesis in fertilized embryos from homozygote mothers is reduced 50% compared to in wild-type embryos
• fertilized embryos from homozygote mothers exhibit incomplete embryonic genome activation compared to in wild-type embryos

cellular
abnormal oocyte morphology ( J:138573 )
• oocytes lack cytoplasmic lattice and intermediate structures found in wild-type oocyte
• oocytes exhibit increased ribosome solubility compared to in wild-type oocytes




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory