Phenotypes associated with this allele

• Allele Symbol: Atp7a^Mo-2Btlr
• Allele Name: mottled 2 Bruce Beutler
• Allele ID: MGI:3806010
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Atp7a^Mo-2Btlr/Atp7a^+	C57BL/6J-Atp7a^Mo-2Btlr	MGI:3806011
ot2	Atp7a^Mo-2Btlr/Y	C57BL/6J-Atp7a^Mo-2Btlr	MGI:3806012

Genotype
MGI:3806011

ht1

• Allelic Composition: Atp7a^Mo-2Btlr/Atp7a⁺
• Genetic Background: C57BL/6J-Atp7a^Mo-2Btlr

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Coat color phenotypes of mutants carrying the Atp7a^Mo-Btlr, Atp7a^Mo-2Btlr, or Atp7a^Mo-3Btlr allele

pigmentation

mosaic coat color ( J:138687 , J:188598 )

♀ • the fur of heterozygous female mice is black with brown stripes on the back, belly and face that appear not to cross the midline; the skin of newborn mice is lighter where the brown stripes will later appear, and the stripes lighten and become more pronounced as the mice age (J:138687)

♀ (J:188598)

integument

mosaic coat color ( J:138687 , J:188598 )

♀ • the fur of heterozygous female mice is black with brown stripes on the back, belly and face that appear not to cross the midline; the skin of newborn mice is lighter where the brown stripes will later appear, and the stripes lighten and become more pronounced as the mice age (J:138687)

♀ (J:188598)

Genotype
MGI:3806012

ot2

• Allelic Composition: Atp7a^Mo-2Btlr/Y
• Genetic Background: C57BL/6J-Atp7a^Mo-2Btlr

Coat color phenotypes of mutants carrying the Atp7a^Mo-Btlr, Atp7a^Mo-2Btlr, or Atp7a^Mo-3Btlr allele

mortality/aging

postnatal lethality, complete penetrance ( J:138687 , J:188598 )

♂ • males that survive to birth die within 20 days (J:138687)

♂ (J:188598)

prenatal lethality, incomplete penetrance ( J:138687 , J:188598 )

♂ • hemizygosity for this mutation results in some prenatal male lethality (J:138687)

♂ (J:188598)

pigmentation

pigmentation phenotype ( J:138687 )

♂N • the eyes and extremities of hemizygous male mice are pigmented

absent coat pigmentation ( J:138687 , J:188598 )

♂ • the skin and, when hair comes in, the coats of surviving hemizygous mutant males lack pigment except of the extremities, so that they resemble animals homozygous for a thermolabile tyrosinase mutation (e.g., Siamese cats) (J:138687)

♂ (J:188598)

integument

absent coat pigmentation ( J:138687 , J:188598 )

♂ • the skin and, when hair comes in, the coats of surviving hemizygous mutant males lack pigment except of the extremities, so that they resemble animals homozygous for a thermolabile tyrosinase mutation (e.g., Siamese cats) (J:138687)

♂ (J:188598)