All Phenotypes Vsig4<tm1Gne> MGI Mouse

About Help FAQ

Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Vsig4^tm1Gne
targeted mutation 1, Genentech
MGI:3806036

Summary

7 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Vsig4^tm1Gne/Vsig4^tm1Gne	C57BL/6-Vsig4^tm1Gne	MGI:6384864
hm2	Vsig4^tm1Gne/Vsig4^tm1Gne	involves: C57BL/6N	MGI:3806097
cn3	Cr1l^tm1.1Song/Cr1l^tm1.1Song Vsig4^tm1Gne/Vsig4^tm1Gne Tg(Cd4-cre)1Cwi/0	involves: 129S6/SvEvTac * C57BL/6N * DBA/2 * SJL	MGI:3838226
cx4	Il1r1^tm1Imx/Il1r1^tm1Imx Vsig4^tm1Gne/Vsig4^tm1Gne	B6.Cg-Il1r1^tm1Imx Vsig4^tm1Gne	MGI:6384866
cx5	Nlrp3^tm2Hhf/Nlrp3^tm2Hhf Vsig4^tm1Gne/Vsig4^tm1Gne	B6.Cg-Nlrp3^tm2Hhf Vsig4^tm1Gne	MGI:6384868
cx6	C3^tm1Hrc/C3^tm1Hrc Cd55^tm1Song/Cd55^tm1Song Cr1l^tm1Hmo/Cr1l^tm1Hmo Vsig4^tm1Gne/Vsig4^tm1Gne	involves: 129/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6N	MGI:3806101
cx7	C3^tm1Hrc/C3^tm1Hrc Vsig4^tm1Gne/Vsig4^tm1Gne	involves: 129/Sv * C57BL/6N	MGI:3806098

Allelic Composition	Vsig4^tm1Gne/Vsig4^tm1Gne
Genetic Background	C57BL/6-Vsig4^tm1Gne

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Vsig4^tm1Gne mutation (0 available); any Vsig4 mutation (10 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

decreased susceptibility to induced colitis ( J:281762 )

• DSS-treated mice exhibit increased survival with reduced weight loss, colon degeneration, loss of epithelium barrier function, and increased cell proliferation in the colon compared with wild-type mice

increased T-helper 1 cell number ( J:281762 )

• in MOG35-55 treated mice

increased T-helper 17 cell number ( J:281762 )

• in MOG35-55 treated mice

abnormal macrophage physiology ( J:281762 )

• enhanced caspase-1-dependent induced pyroptosis peritoneal exudate macrophages

increased circulating interleukin-1 beta level ( J:281762 )

• in MOG35-55 or DSS-treated mice

increased interleukin-1 beta secretion ( J:281762 )

• from peritoneal exudate macrophages stimulated with LPS and nigericin, LPS and ATP, LPS and silica, or dsDNA treatment

• from macrophages of MOG35-55 treated mice

increased susceptibility to experimental autoimmune encephalomyelitis ( J:281762 )

• MOG35-55 treated mice exhibit increased EAE clinical score, increased leukocyte spinal cord infiltration, increased TH1 and TH17 cells in the spinal cord and spleen, and increased IL-beta expression form macrophages compared with wild-type mice

digestive/alimentary system

abnormal enterocyte proliferation ( J:281762 )

• DSS-treated mice exhibit increased cell proliferation in the colon compared with wild-type mice

decreased susceptibility to induced colitis ( J:281762 )

homeostasis/metabolism

increased circulating interleukin-1 beta level ( J:281762 )

• in MOG35-55 or DSS-treated mice

hematopoietic system

increased T-helper 1 cell number ( J:281762 )

• in MOG35-55 treated mice

increased T-helper 17 cell number ( J:281762 )

• in MOG35-55 treated mice

abnormal macrophage physiology ( J:281762 )

• enhanced caspase-1-dependent induced pyroptosis peritoneal exudate macrophages

cellular

abnormal enterocyte proliferation ( J:281762 )

• DSS-treated mice exhibit increased cell proliferation in the colon compared with wild-type mice

Allelic Composition	Vsig4^tm1Gne/Vsig4^tm1Gne
Genetic Background	involves: C57BL/6N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Vsig4^tm1Gne mutation (0 available); any Vsig4 mutation (10 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

increased susceptibility to induced morbidity/mortality ( J:138691 )

• following infection with Listeria monocytogenes, mice exhibit increased mortality compared to similarly treated wild-type mice

immune system

increased susceptibility to bacterial infection ( J:138691 )

• following infection with Listeria monocytogenes, mice exhibit increased bacterial counts in the blood, spleen and lungs, increased serum cytokine levels, reduced splenocyte numbers by day 6 of infection, reduced bacterial clearance and increased mortality compared to similarly treated wild-type mice

• following infection with Staphylococcus aureus, mice exhibit increased blood and bacterial counts compared to in similarly treated wild-type mice

Allelic Composition	Cr1l^tm1.1Song/Cr1l^tm1.1Song Vsig4^tm1Gne/Vsig4^tm1Gne Tg(Cd4-cre)1Cwi/0
Genetic Background	involves: 129S6/SvEvTac * C57BL/6N * DBA/2 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cr1l^tm1.1Song mutation (0 available); any Cr1l mutation (30 available)
Tg(Cd4-cre)1Cwi mutation (10 available)
Vsig4^tm1Gne mutation (0 available); any Vsig4 mutation (10 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

decreased lymphocyte cell number ( J:146538 )

• mice exhibit peripheral T cell lymphopenia

immune system

decreased lymphocyte cell number ( J:146538 )

• mice exhibit peripheral T cell lymphopenia

Allelic Composition	Il1r1^tm1Imx/Il1r1^tm1Imx Vsig4^tm1Gne/Vsig4^tm1Gne
Genetic Background	B6.Cg-Il1r1^tm1Imx Vsig4^tm1Gne

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il1r1^tm1Imx mutation (4 available); any Il1r1 mutation (39 available)
Vsig4^tm1Gne mutation (0 available); any Vsig4 mutation (10 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

increased susceptibility to induced colitis ( J:281762 )

• DSS-treated mice exhibit more severe colitis compared with wild-type mice and Vsig4^tm1Gne homozygotes

decreased T helper 1 cell number ( J:281762 )

• in MOG35-55 treated mice

decreased T-helper 17 cell number ( J:281762 )

• in MOG35-55 treated mice

decreased susceptibility to experimental autoimmune encephalomyelitis ( J:281762 )

• MOG35-55 treated mice exhibit delayed onset and reduced clinical score, reduced leukocyte spinal cord infiltration, and decreased TH1 and TH17 cells in the spinal cord and spleen compared with wild-type mice and Vsig4^tm1Gne homozygotes

digestive/alimentary system

increased susceptibility to induced colitis ( J:281762 )

• DSS-treated mice exhibit more severe colitis compared with wild-type mice and Vsig4^tm1Gne homozygotes

hematopoietic system

decreased T helper 1 cell number ( J:281762 )

• in MOG35-55 treated mice

decreased T-helper 17 cell number ( J:281762 )

• in MOG35-55 treated mice

Allelic Composition	Nlrp3^tm2Hhf/Nlrp3^tm2Hhf Vsig4^tm1Gne/Vsig4^tm1Gne
Genetic Background	B6.Cg-Nlrp3^tm2Hhf Vsig4^tm1Gne

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nlrp3^tm2Hhf mutation (1 available); any Nlrp3 mutation (64 available)
Vsig4^tm1Gne mutation (0 available); any Vsig4 mutation (10 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

decreased susceptibility to experimental autoimmune encephalomyelitis ( J:281762 )

• MOG35-55 treated mice exhibit reduced clinical score compared with Vsig4^tm1Gne homozygotes

Allelic Composition	C3^tm1Hrc/C3^tm1Hrc Cd55^tm1Song/Cd55^tm1Song Cr1l^tm1Hmo/Cr1l^tm1Hmo Vsig4^tm1Gne/Vsig4^tm1Gne
Genetic Background	involves: 129/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
C3^tm1Hrc mutation (2 available); any C3 mutation (103 available)
Cd55^tm1Song mutation (2 available); any Cd55 mutation (39 available)
Cr1l^tm1Hmo mutation (0 available); any Cr1l mutation (30 available)
Vsig4^tm1Gne mutation (0 available); any Vsig4 mutation (10 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

abnormal platelet physiology ( J:138410 )

• unlike in C3^tm1Hrc Cd55^tm1Song Cr1l^tm1Hmo homozygotes, platelet half-life is normal

homeostasis/metabolism

abnormal platelet physiology ( J:138410 )

• unlike in C3^tm1Hrc Cd55^tm1Song Cr1l^tm1Hmo homozygotes, platelet half-life is normal

Allelic Composition	C3^tm1Hrc/C3^tm1Hrc Vsig4^tm1Gne/Vsig4^tm1Gne
Genetic Background	involves: 129/Sv * C57BL/6N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
C3^tm1Hrc mutation (2 available); any C3 mutation (103 available)
Vsig4^tm1Gne mutation (0 available); any Vsig4 mutation (10 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

immune system phenotype ( J:138691 )

N	• following infection with Staphylococcus aureus, bacterial counts are normal

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24