nervous system
N |
• mice show no significant differences relative to triple mutants carrying wild-type human SOD1, in the rotarod test when tested at 300 days and later
|
• significant decrease in number of spinal motor neurons (MNs) compared to wild-type and transgenic controls is observed at 450 days of age
|
• significant decrease in number of axons in L5 anterior root at 450 days is observed compared to triple mutants expressing wild-type human SOD1
|
growth/size/body
• after 300 days, mean body weight is reduced relative to wild-type or to triple mutants carrying the wild-type human SOD1 gene
|