About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tg(RHO-VEGFA)V-6Camp
transgene insertion V-6,Peter A Campochiaro
MGI:3806310
Summary 5 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cx1
 		Adam15tm1Dgen/Adam15tm1Dgen
Tg(RHO-VEGFA)V-6Camp/0 		involves: 129P2/OlaHsd * C57BL/6 MGI:3806314
cx2
 		Nos2tm1Lau/Nos2tm1Lau
Tg(RHO-VEGFA)V-6Camp/0 		involves: 129P2/OlaHsd * C57BL/6J MGI:4366933
cx3
 		Nos3tm1Plh/Nos3tm1Plh
Tg(RHO-VEGFA)V-6Camp/0 		involves: 129S4/SvJae * C57BL/6J MGI:4366931
cx4
 		Nos1tm1Plh/Nos1tm1Plh
Tg(RHO-VEGFA)V-6Camp/0 		involves: 129S4/SvJae * C57BL/6J MGI:4366932
tg5
 		Tg(RHO-VEGFA)V-6Camp/0 involves: C57BL/6J MGI:3806316


Genotype
MGI:3806314
cx1
Allelic
Composition		 Adam15tm1Dgen/Adam15tm1Dgen
Tg(RHO-VEGFA)V-6Camp/0
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adam15tm1Dgen mutation (0 available); any Adam15 mutation (37 available)
Tg(RHO-VEGFA)V-6Camp mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
abnormal induced retina neovascularization ( J:138010 )
• reduction in subretinal neovascularization compared to transgenic littermates wild-type for Adam15

vision/eye
abnormal induced retina neovascularization ( J:138010 )
• reduction in subretinal neovascularization compared to transgenic littermates wild-type for Adam15




Genotype
MGI:4366933
cx2
Allelic
Composition		 Nos2tm1Lau/Nos2tm1Lau
Tg(RHO-VEGFA)V-6Camp/0
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nos2tm1Lau mutation (8 available); any Nos2 mutation (67 available)
Tg(RHO-VEGFA)V-6Camp mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
abnormal angiogenesis ( J:106207 )
• compared to mice carrying Tg(RHO-VEGFA)V-6Camp and heterozygous for Nos2tm1Lau neovascularization of the retina is significantly reduced




Genotype
MGI:4366931
cx3
Allelic
Composition		 Nos3tm1Plh/Nos3tm1Plh
Tg(RHO-VEGFA)V-6Camp/0
Genetic
Background		 involves: 129S4/SvJae * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nos3tm1Plh mutation (1 available); any Nos3 mutation (58 available)
Tg(RHO-VEGFA)V-6Camp mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
abnormal angiogenesis ( J:106207 )
• compared to mice carrying Tg(RHO-VEGFA)V-6Camp and heterozygous for Nos3tm1Plh neovascularization of the retina is significantly reduced




Genotype
MGI:4366932
cx4
Allelic
Composition		 Nos1tm1Plh/Nos1tm1Plh
Tg(RHO-VEGFA)V-6Camp/0
Genetic
Background		 involves: 129S4/SvJae * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nos1tm1Plh mutation (3 available); any Nos1 mutation (84 available)
Tg(RHO-VEGFA)V-6Camp mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
abnormal angiogenesis ( J:106207 )
• compared to mice carrying Tg(RHO-VEGFA)V-6Camp and heterozygous for Nos1tm1Plh neovascularization of the retina is significantly reduced




Genotype
MGI:3806316
tg5
Allelic
Composition		 Tg(RHO-VEGFA)V-6Camp/0
Genetic
Background		 involves: C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
retina neovascularization ( J:41411 , J:138010 )
• focal areas of intraretinal and subretinal neovascularization are seen at 1 month of age (J:41411)
• blood vessels extend from the inner nuclear layer through the outer nuclear layer and form small networks of vessels in the outer segment layer (J:41411)
• at 3 months of age, vessels extend down from the inner nuclear layer to form a large plexus of vessels in the subretinal space (J:41411)
• in some cases vessel lumens and cavities within the plexus contain retinal pigment epithelial cells (J:41411)
increased vascular permeability ( J:41411 )
• at 1, 3, and 4 months of age leakage is detected in the retinal vasculature

vision/eye
retina neovascularization ( J:41411 , J:138010 )
• focal areas of intraretinal and subretinal neovascularization are seen at 1 month of age (J:41411)
• blood vessels extend from the inner nuclear layer through the outer nuclear layer and form small networks of vessels in the outer segment layer (J:41411)
• at 3 months of age, vessels extend down from the inner nuclear layer to form a large plexus of vessels in the subretinal space (J:41411)
• in some cases vessel lumens and cavities within the plexus contain retinal pigment epithelial cells (J:41411)
abnormal retina pigment epithelium morphology ( J:41411 )
• proliferating retinal pigment epithelial cells are found around some site of neovascularization
• some cells around the neovascularization sites contain large cavities

pigmentation
abnormal retina pigment epithelium morphology ( J:41411 )
• proliferating retinal pigment epithelial cells are found around some site of neovascularization
• some cells around the neovascularization sites contain large cavities




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory