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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tg(RHO-VEGFA)V-6Camp
transgene insertion V-6,Peter A Campochiaro
MGI:3806310
Summary 5 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cx1
 		Adam15tm1Dgen/Adam15tm1Dgen
Tg(RHO-VEGFA)V-6Camp/0 		involves: 129P2/OlaHsd * C57BL/6 MGI:3806314
cx2
 		Nos2tm1Lau/Nos2tm1Lau
Tg(RHO-VEGFA)V-6Camp/0 		involves: 129P2/OlaHsd * C57BL/6J MGI:4366933
cx3
 		Nos3tm1Plh/Nos3tm1Plh
Tg(RHO-VEGFA)V-6Camp/0 		involves: 129S4/SvJae * C57BL/6J MGI:4366931
cx4
 		Nos1tm1Plh/Nos1tm1Plh
Tg(RHO-VEGFA)V-6Camp/0 		involves: 129S4/SvJae * C57BL/6J MGI:4366932
tg5
 		Tg(RHO-VEGFA)V-6Camp/0 involves: C57BL/6J MGI:3806316


Genotype
MGI:3806314
cx1
Allelic
Composition		 Adam15tm1Dgen/Adam15tm1Dgen
Tg(RHO-VEGFA)V-6Camp/0
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adam15tm1Dgen mutation (0 available); any Adam15 mutation (37 available)
Tg(RHO-VEGFA)V-6Camp mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
abnormal induced retina neovascularization ( J:138010 )
• reduction in subretinal neovascularization compared to transgenic littermates wild-type for Adam15

vision/eye
abnormal induced retina neovascularization ( J:138010 )
• reduction in subretinal neovascularization compared to transgenic littermates wild-type for Adam15




Genotype
MGI:4366933
cx2
Allelic
Composition		 Nos2tm1Lau/Nos2tm1Lau
Tg(RHO-VEGFA)V-6Camp/0
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nos2tm1Lau mutation (8 available); any Nos2 mutation (67 available)
Tg(RHO-VEGFA)V-6Camp mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
abnormal angiogenesis ( J:106207 )
• compared to mice carrying Tg(RHO-VEGFA)V-6Camp and heterozygous for Nos2tm1Lau neovascularization of the retina is significantly reduced




Genotype
MGI:4366931
cx3
Allelic
Composition		 Nos3tm1Plh/Nos3tm1Plh
Tg(RHO-VEGFA)V-6Camp/0
Genetic
Background		 involves: 129S4/SvJae * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nos3tm1Plh mutation (1 available); any Nos3 mutation (58 available)
Tg(RHO-VEGFA)V-6Camp mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
abnormal angiogenesis ( J:106207 )
• compared to mice carrying Tg(RHO-VEGFA)V-6Camp and heterozygous for Nos3tm1Plh neovascularization of the retina is significantly reduced




Genotype
MGI:4366932
cx4
Allelic
Composition		 Nos1tm1Plh/Nos1tm1Plh
Tg(RHO-VEGFA)V-6Camp/0
Genetic
Background		 involves: 129S4/SvJae * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nos1tm1Plh mutation (3 available); any Nos1 mutation (84 available)
Tg(RHO-VEGFA)V-6Camp mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
abnormal angiogenesis ( J:106207 )
• compared to mice carrying Tg(RHO-VEGFA)V-6Camp and heterozygous for Nos1tm1Plh neovascularization of the retina is significantly reduced




Genotype
MGI:3806316
tg5
Allelic
Composition		 Tg(RHO-VEGFA)V-6Camp/0
Genetic
Background		 involves: C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
retina neovascularization ( J:41411 , J:138010 )
• focal areas of intraretinal and subretinal neovascularization are seen at 1 month of age (J:41411)
• blood vessels extend from the inner nuclear layer through the outer nuclear layer and form small networks of vessels in the outer segment layer (J:41411)
• at 3 months of age, vessels extend down from the inner nuclear layer to form a large plexus of vessels in the subretinal space (J:41411)
• in some cases vessel lumens and cavities within the plexus contain retinal pigment epithelial cells (J:41411)
increased vascular permeability ( J:41411 )
• at 1, 3, and 4 months of age leakage is detected in the retinal vasculature

vision/eye
retina neovascularization ( J:41411 , J:138010 )
• focal areas of intraretinal and subretinal neovascularization are seen at 1 month of age (J:41411)
• blood vessels extend from the inner nuclear layer through the outer nuclear layer and form small networks of vessels in the outer segment layer (J:41411)
• at 3 months of age, vessels extend down from the inner nuclear layer to form a large plexus of vessels in the subretinal space (J:41411)
• in some cases vessel lumens and cavities within the plexus contain retinal pigment epithelial cells (J:41411)
abnormal retina pigment epithelium morphology ( J:41411 )
• proliferating retinal pigment epithelial cells are found around some site of neovascularization
• some cells around the neovascularization sites contain large cavities

pigmentation
abnormal retina pigment epithelium morphology ( J:41411 )
• proliferating retinal pigment epithelial cells are found around some site of neovascularization
• some cells around the neovascularization sites contain large cavities




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Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory