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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Rtn4rtm1.1Pado
targeted mutation 1.1, Patrick Doherty
MGI:3806671
Summary 5 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Rtn4rtm1.1Pado/Rtn4rtm1.1Pado involves: 129S/SvEvBrd * 129S4/SvJae MGI:3806676
cx2
 		Rtn4rtm1.1Pado/Rtn4rtm1.1Pado
Rtn4rl1tm1.1Rojg/Rtn4rl1tm1.1Rojg
Rtn4rl2tm1.1Pado/Rtn4rl2tm1.1Pado 		involves: 129S/SvEvBrd * 129S4/SvJae MGI:5462102
cx3
 		Rtn4rtm1.1Pado/Rtn4rtm1.1Pado
Rtn4rl1tm1.1Rojg/Rtn4rl1tm1.1Rojg 		involves: 129S/SvEvBrd * 129S4/SvJae MGI:5462103
cx4
 		Ptprstm1Mtr/Ptprstm1Mtr
Rtn4rtm1.1Pado/Rtn4rtm1.1Pado
Rtn4rl1tm1.1Rojg/Rtn4rl1tm1.1Rojg 		involves: 129S/SvEvBrd * 129S4/SvJae MGI:5462104
cx5
 		Rtn4rtm1.1Pado/Rtn4rtm1.1Pado
Rtn4rl2tm1.1Pado/Rtn4rl2tm1.1Pado 		involves: 129S/SvEvBrd * 129S4/SvJae MGI:5462105


Genotype
MGI:3806676
hm1
Allelic
Composition		 Rtn4rtm1.1Pado/Rtn4rtm1.1Pado
Genetic
Background		 involves: 129S/SvEvBrd * 129S4/SvJae
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rtn4rtm1.1Pado mutation (0 available); any Rtn4r mutation (24 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal axon extension ( J:138580 )
• unlike in wild-type mice, neurite outgrowth is not sensitive to treatment with trisialoganglioside (GT1b) antibodies or soluble MAG

cellular
abnormal axon extension ( J:138580 )
• unlike in wild-type mice, neurite outgrowth is not sensitive to treatment with trisialoganglioside (GT1b) antibodies or soluble MAG




Genotype
MGI:5462102
cx2
Allelic
Composition		 Rtn4rtm1.1Pado/Rtn4rtm1.1Pado
Rtn4rl1tm1.1Rojg/Rtn4rl1tm1.1Rojg
Rtn4rl2tm1.1Pado/Rtn4rl2tm1.1Pado
Genetic
Background		 involves: 129S/SvEvBrd * 129S4/SvJae
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rtn4rl1tm1.1Rojg mutation (0 available); any Rtn4rl1 mutation (25 available)
Rtn4rl2tm1.1Pado mutation (0 available); any Rtn4rl2 mutation (24 available)
Rtn4rtm1.1Pado mutation (0 available); any Rtn4r mutation (24 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
enhanced central nervous system regeneration ( J:191258 )
• modestly improved recovery of retinal ganglion cell axons from retro-orbital optic nerve crush
abnormal neuron physiology ( J:191258 )
• cerebellar granule neurons experience significant but incomplete release of growth inhibition in culture
• strong inhibition of neuron growth when challenged with high concentrations of chondroitin sulfate proteoglycans
• neurites are significantly longer than those of any controls




Genotype
MGI:5462103
cx3
Allelic
Composition		 Rtn4rtm1.1Pado/Rtn4rtm1.1Pado
Rtn4rl1tm1.1Rojg/Rtn4rl1tm1.1Rojg
Genetic
Background		 involves: 129S/SvEvBrd * 129S4/SvJae
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rtn4rl1tm1.1Rojg mutation (0 available); any Rtn4rl1 mutation (25 available)
Rtn4rtm1.1Pado mutation (0 available); any Rtn4r mutation (24 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
enhanced central nervous system regeneration ( J:191258 )
• modestly improved recovery of retinal ganglion cell axons from retro-orbital optic nerve crush




Genotype
MGI:5462104
cx4
Allelic
Composition		 Ptprstm1Mtr/Ptprstm1Mtr
Rtn4rtm1.1Pado/Rtn4rtm1.1Pado
Rtn4rl1tm1.1Rojg/Rtn4rl1tm1.1Rojg
Genetic
Background		 involves: 129S/SvEvBrd * 129S4/SvJae
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ptprstm1Mtr mutation (0 available); any Ptprs mutation (78 available)
Rtn4rl1tm1.1Rojg mutation (0 available); any Rtn4rl1 mutation (25 available)
Rtn4rtm1.1Pado mutation (0 available); any Rtn4r mutation (24 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
enhanced central nervous system regeneration ( J:191258 )
• considerably improved recovery of retinal ganglion cell axons from retro-orbital optic nerve crush




Genotype
MGI:5462105
cx5
Allelic
Composition		 Rtn4rtm1.1Pado/Rtn4rtm1.1Pado
Rtn4rl2tm1.1Pado/Rtn4rl2tm1.1Pado
Genetic
Background		 involves: 129S/SvEvBrd * 129S4/SvJae
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rtn4rl2tm1.1Pado mutation (0 available); any Rtn4rl2 mutation (24 available)
Rtn4rtm1.1Pado mutation (0 available); any Rtn4r mutation (24 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
nervous system phenotype ( J:191258 )
N
• no improvement relative to controls in recovery of retinal ganglion cell axons from retro-orbital optic nerve crush




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory