Phenotypes associated with this allele

• Allele Symbol: Trem2^tm1Cln
• Allele Name: targeted mutation 1, Marco Colonna
• Allele ID: MGI:3806795
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Trem2^tm1Cln/Trem2^tm1Cln	B6.129P2-Trem2^tm1Cln	MGI:3806796

Genotype
MGI:3806796

hm1

• Allelic Composition: Trem2^tm1Cln/Trem2^tm1Cln
• Genetic Background: B6.129P2-Trem2^tm1Cln

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal interferon level ( J:138057 )

• no IFN gamma detected in response to agonists for Tlr2, 4, 6, and 9

abnormal interleukin level ( J:138057 )

• no Il12 detected in response to agonists for Tlr2, 4, 6, and 9

• increased Il6 production in response to LPS by bone marrow derived macrophage and peritoneal macrophage

abnormal tumor necrosis factor level ( J:138057 )

• increased Tnf alpha production by bone marrow derived macrophage and peritoneal macrophage in response to agonists for Tlr2, 4, 6, and 9

homeostasis/metabolism

abnormal interferon level ( J:138057 )

• no IFN gamma detected in response to agonists for Tlr2, 4, 6, and 9

abnormal interleukin level ( J:138057 )

• no Il12 detected in response to agonists for Tlr2, 4, 6, and 9

• increased Il6 production in response to LPS by bone marrow derived macrophage and peritoneal macrophage

abnormal tumor necrosis factor level ( J:138057 )

• increased Tnf alpha production by bone marrow derived macrophage and peritoneal macrophage in response to agonists for Tlr2, 4, 6, and 9