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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		E2f3tm3.1Gle
targeted mutation 3.1, Gustavo Leone
MGI:3806817
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		E2f3tm3.1Gle/E2f3tm3.1Gle FVB.129S6-E2f3tm3.1Gle MGI:3806836
cx2
 		E2f1tm1Meg/E2f1tm1Meg
E2f2tm1Zubi/E2f2tm1Zubi
E2f3tm3.1Gle/E2f3tm3.1Gle 		involves: 129 * FVB/N * NIH Black Swiss MGI:3806840
cx3
 		E2f2tm1Zubi/E2f2tm1Zubi
E2f3tm3.1Gle/E2f3tm3.1Gle 		involves: 129S1/Sv * 129S6/SvEvTac * FVB/N * NIH Black Swiss MGI:3806845
cx4
 		E2f1tm1Meg/E2f1tm1Meg
E2f3tm3.1Gle/E2f3tm3.1Gle 		involves: 129S4/SvJae * 129S6/SvEvTac * FVB/N * NIH Black Swiss MGI:3806846


Genotype
MGI:3806836
hm1
Allelic
Composition		 E2f3tm3.1Gle/E2f3tm3.1Gle
Genetic
Background		 FVB.129S6-E2f3tm3.1Gle
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
E2f3tm3.1Gle mutation (0 available); any E2f3 mutation (33 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
mortality/aging ( J:138289 )
N
• unlike mice lacking both isoforms, in mice lacking only the E2f3a isoform no significant embryonic lethality is seen




Genotype
MGI:3806840
cx2
Allelic
Composition		 E2f1tm1Meg/E2f1tm1Meg
E2f2tm1Zubi/E2f2tm1Zubi
E2f3tm3.1Gle/E2f3tm3.1Gle
Genetic
Background		 involves: 129 * FVB/N * NIH Black Swiss
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
E2f1tm1Meg mutation (2 available); any E2f1 mutation (28 available)
E2f2tm1Zubi mutation (1 available); any E2f2 mutation (29 available)
E2f3tm3.1Gle mutation (0 available); any E2f3 mutation (33 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
mortality/aging ( J:138289 )
N
• unlike triple mutant mice lacking expression of the E2f3a isoform, triple mutant mice lacking the E2f3b isoform survive to adulthood

cellular
decreased cell proliferation ( J:138289 )
• in MEFs after 5 and 6 days in culture compared to littermate-derived controls

growth/size/body
decreased body weight ( J:138289 )




Genotype
MGI:3806845
cx3
Allelic
Composition		 E2f2tm1Zubi/E2f2tm1Zubi
E2f3tm3.1Gle/E2f3tm3.1Gle
Genetic
Background		 involves: 129S1/Sv * 129S6/SvEvTac * FVB/N * NIH Black Swiss
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
E2f2tm1Zubi mutation (1 available); any E2f2 mutation (29 available)
E2f3tm3.1Gle mutation (0 available); any E2f3 mutation (33 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:138289 )
• develop normally and have a normal lifespan




Genotype
MGI:3806846
cx4
Allelic
Composition		 E2f1tm1Meg/E2f1tm1Meg
E2f3tm3.1Gle/E2f3tm3.1Gle
Genetic
Background		 involves: 129S4/SvJae * 129S6/SvEvTac * FVB/N * NIH Black Swiss
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
E2f1tm1Meg mutation (2 available); any E2f1 mutation (28 available)
E2f3tm3.1Gle mutation (0 available); any E2f3 mutation (33 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
growth/size/body
decreased body weight ( J:138289 )
• young mice are slightly but significantly smaller
• but by 90 days of age no significant difference in weight is detected




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory