Phenotypes associated with this allele

• Allele Symbol: Bpnt2^{Gt(KST245)Byg}
• Allele Name: gene trap KST245, BayGenomics
• Allele ID: MGI:3806990
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Bpnt2^Gt(KST245)Byg/Bpnt2^Gt(KST245)Byg	B6.129P2-Bpnt2^Gt(KST245)Byg	MGI:3809000

Genotype
MGI:3809000

hm1

• Allelic Composition: Bpnt2^{Gt(KST245)Byg}/Bpnt2^{Gt(KST245)Byg}
• Genetic Background: B6.129P2-Bpnt2^{Gt(KST245)Byg}

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

perinatal lethality ( J:137353 )

growth/size/body

cleft secondary palate ( J:137353 )

round head ( J:137353 )

• rounded head

shortened head ( J:137353 )

disproportionate dwarf ( J:137353 )

• neonates display severe dwarfism

craniofacial

cleft secondary palate ( J:137353 )

round head ( J:137353 )

• rounded head

shortened head ( J:137353 )

limbs/digits/tail

abnormal knee joint morphology ( J:137353 )

• knee joint fails to form

short limbs ( J:137353 )

• neonates have stunted limbs

skeleton

skeleton phenotype ( J:137353 )

N • clavicles and cranial vault relatively normal (membrane bone)

disorganized long bone epiphyseal plate ( J:137353 )

• growth plate fails to develop normal pseudocolumnar organization

• growth plate is hypocellular

• after E15.5, ectopic chondrocytes impinge on primary ossification centers

abnormal axial skeleton morphology ( J:137353 )

abnormal thoracic cage morphology ( J:137353 )

• hypoplastic ribcage

axial skeleton hypoplasia ( J:137353 )

• hypoplastic ribcage

abnormal cartilage development ( J:137353 )

• defects in chondrogenesis apparent by E12.5

• expression patterns of chondrocyte markers suggests delayed chondrocyte maturation

abnormal joint morphology ( J:137353 )

• knee joint fails to form

• abnormal and misoriented joint formation in digits

• involving non chondrogenic cavities extending longitudinally and expressing joint formation markers

abnormal knee joint morphology ( J:137353 )

• knee joint fails to form

digestive/alimentary system

cleft secondary palate ( J:137353 )