Phenotypes associated with this allele

• Allele Symbol: Spi1^tm1.1Rpd
• Allele Name: targeted mutation 1.1, Rodney P DeKoter
• Allele ID: MGI:3806995
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Spi1^tm1.1Rpd/Spi1^tm1.1Rpd	involves: 129/Sv * Black Swiss * FVB/N	MGI:3807005

Genotype
MGI:3807005

hm1

• Allelic Composition: Spi1^tm1.1Rpd/Spi1^tm1.1Rpd
• Genetic Background: involves: 129/Sv * Black Swiss * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:138501 )

• mice die within 7 days of birth

hematopoietic system

abnormal common myeloid progenitor cell morphology ( J:138501 )

• fetal liver progenitor cells form fewer colonies when cultured with granulocyte-colony stimulating factor, macrophage colony stimulating factor or IL3, IL6 and stem cell factor compared to fetal liver cells from Sfpi1^tm1Rpd and wild-type mice

• after several passages, fetal liver cells grow faster than wild-type cells in culture and resemble immature blast cells instead of immature mast cells