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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Foxs1tm1Kmor
targeted mutation 1, Ken-ichirou Morohashi
MGI:3807067
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Foxs1tm1Kmor/Foxs1tm1Kmor involves: 129P2/OlaHsd * C57BL/6JJcl MGI:3807083
ht2
 		Foxs1tm1Kmor/Foxs1+ involves: 129P2/OlaHsd * C57BL/6JJcl MGI:3807084


Genotype
MGI:3807083
hm1
Allelic
Composition		 Foxs1tm1Kmor/Foxs1tm1Kmor
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6JJcl
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Foxs1tm1Kmor mutation (0 available); any Foxs1 mutation (23 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype

Testicular vasculature abnormalities in Foxs1tm1Kmor/Foxs1tm1Kmor mice

cardiovascular system
abnormal blood vessel endothelium morphology ( J:138911 )
• mice exhibit gaps in the endothelial lining of the testicular and coelomic vessels
• periendothelial cells exhibit a 3-fold increase in apoptosis rates compared to in wild-type mice
testicular hemorrhage ( J:138911 )
• 33% of mice exhibit accumulation of blood in the central part of the testes

endocrine/exocrine glands
testicular hemorrhage ( J:138911 )
• 33% of mice exhibit accumulation of blood in the central part of the testes

reproductive system
reproductive system phenotype ( J:138911 )
N
• despite defects in testicular vasculature, male mice exhibit normal fertility
testicular hemorrhage ( J:138911 )
• 33% of mice exhibit accumulation of blood in the central part of the testes




Genotype
MGI:3807084
ht2
Allelic
Composition		 Foxs1tm1Kmor/Foxs1+
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6JJcl
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Foxs1tm1Kmor mutation (0 available); any Foxs1 mutation (23 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
testicular hemorrhage ( J:138911 )
• 15% of mice exhibit accumulation of blood in the central part of the testes

endocrine/exocrine glands
testicular hemorrhage ( J:138911 )
• 15% of mice exhibit accumulation of blood in the central part of the testes

reproductive system
testicular hemorrhage ( J:138911 )
• 15% of mice exhibit accumulation of blood in the central part of the testes




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory