All Phenotypes Tg(Cyp17a1-icre)AJako MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Creb1^tm3Gsc/Creb1^tm3Gsc Tg(Cyp17a1-icre)AJako/0	involves: 129P2/OlaHsd * C57BL/6 * SJL	MGI:4949155
cn2	Creb1^tm3Gsc/Creb1⁺ Gprc6a^tm1.1Kry/Gprc6a⁺ Tg(Cyp17a1-icre)AJako/0	involves: 129P2/OlaHsd * C57BL/6 * SJL	MGI:4949156
cn3	Esr1^tm1.2Mma/Esr1^tm1.2Mma Tg(Cyp17a1-icre)AJako/0	involves: 129S2/SvPas * C57BL/6 * SJL	MGI:4361176
cn4	Map2k1^tm1Chrn/Map2k1^tm1Chrn Map2k2^tm1Chrn/Map2k2^tm1Chrn Tg(Cyp17a1-icre)AJako/0	involves: 129/Sv * C57BL/6 * C57BL/6J * SJL	MGI:6856826
cn5	Bglap/Bglap2^tm3.1Kry/Bglap⁺ Gprc6a^tm1.1Kry/Gprc6a⁺ Tg(Cyp17a1-icre)AJako/0	involves: C57BL/6J	MGI:4949151
cn6	Bglap/Bglap2^tm3.1Kry/Bglap2⁺ Gprc6a^tm1.1Kry/Gprc6a⁺ Tg(Cyp17a1-icre)AJako/0	involves: C57BL/6J	MGI:4949152
cn7	Gprc6a^tm1.1Kry/Gprc6a^tm1.1Kry Tg(Cyp17a1-icre)AJako/0	involves: C57BL/6J	MGI:4949150
cn8	Bglap/Bglap2^tm3.1Kry/Bglap/Bglap2^tm3.1Kry Tg(Cyp17a1-icre)AJako/0	involves: C57BL/6 * SJL	MGI:4949149
cn9	Bglap/Bglap2^tm3.1Kry/Bglap/Bglap2^tm3.1Kry Tg(Cyp17a1-icre)AJako/0	involves: C57BL/6 * SJL	MGI:4949148

Allelic Composition	Creb1^tm3Gsc/Creb1^tm3Gsc Tg(Cyp17a1-icre)AJako/0
Genetic Background	involves: 129P2/OlaHsd * C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Creb1^tm3Gsc mutation (2 available); any Creb1 mutation (61 available)
Tg(Cyp17a1-icre)AJako mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

oligozoospermia ( J:170888 )

• at 12 weeks

decreased seminal vesicle weight ( J:170888 )

• at 12 weeks

small testis ( J:170888 )

• at 12 weeks

decreased testis weight ( J:170888 )

• at 12 weeks

decreased epididymis weight ( J:170888 )

• at 12 weeks

homeostasis/metabolism

decreased circulating testosterone level ( J:170888 )

• at 12 weeks

endocrine/exocrine glands

decreased seminal vesicle weight ( J:170888 )

• at 12 weeks

small testis ( J:170888 )

• at 12 weeks

decreased testis weight ( J:170888 )

• at 12 weeks

cellular

oligozoospermia ( J:170888 )

• at 12 weeks

Allelic Composition	Creb1^tm3Gsc/Creb1⁺ Gprc6a^tm1.1Kry/Gprc6a⁺ Tg(Cyp17a1-icre)AJako/0
Genetic Background	involves: 129P2/OlaHsd * C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Creb1^tm3Gsc mutation (2 available); any Creb1 mutation (61 available)
Gprc6a^tm1.1Kry mutation (1 available); any Gprc6a mutation (67 available)
Tg(Cyp17a1-icre)AJako mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

oligozoospermia ( J:170888 )

decreased seminal vesicle weight ( J:170888 )

small testis ( J:170888 )

decreased testis weight ( J:170888 )

decreased epididymis weight ( J:170888 )

homeostasis/metabolism

decreased circulating testosterone level ( J:170888 )

endocrine/exocrine glands

decreased seminal vesicle weight ( J:170888 )

small testis ( J:170888 )

decreased testis weight ( J:170888 )

cellular

oligozoospermia ( J:170888 )

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

oocyte degeneration ( J:151908 )

• following induction of superovulation with PMSG and hCG, the majority of mutant oocytes exhibit signs of degeneration

mortality/aging

early reproductive senescence ( J:151908 )

• although mutant females display normal fertility and cycling at 2-3 months of age, they gradually lose fertility leading to near complete infertility by 6 months of age

reproductive system

ovary hemorrhage ( J:151908 )

• at 4 months of age, mutant females display signs of hemorrhagic ovarian cysts; however, hemorrhagic cysts are significantly fewer than those observed in Esr1^tm1.1Mma females

• following injection of PMSG alone or PMSG+hCG, mutant ovaries develop multiple hemorrhagic follicles, rarely observed in wild-type ovaries

oocyte degeneration ( J:151908 )

• following induction of superovulation with PMSG and hCG, the majority of mutant oocytes exhibit signs of degeneration

abnormal ovary morphology ( J:151908 )

• at 4 months of age, mutant ovaries display interstitial hypertrophy

decreased corpora lutea number ( J:151908 )

• at 4 months of age, mutant females display reduced numbers of corpora lutea relative to age-matched control females

abnormal ovarian follicle number ( J:151908 )

• at 4 months of age, mutant females exhibit increased numbers of late preantral and early antral stage follicles

abnormal theca cell layer morphology ( J:151908 )

• following induction of superovulation with PMSG +hCG, most theca cells in mutant ovaries are abnormally located in interstitial areas, in contrast to wild-types ovaries where Cyp17-positive cells are mostly found in the theca interna of preovulatory follicles

increased theca cell number ( J:151908 )

• following induction of superovulation with PMSG +hCG injections, ovaries of 6-month-old mutant females are more heavily populated with theca (Cyp17-positive) cells than wild-type ovaries

• similarly, on the day of diestrus, ovaries of 4- and 10-month-old mutant females exhibit higher numbers of Cyp17-positive cells than wild-type ovaries

ovary cyst ( J:151908 )

• at 4 months of age, unstimulated mutant females display signs of hemorrhagic ovarian cysts; however, hemorrhagic cysts are significantly fewer than those observed in Esr1^tm1.1Mma females

early reproductive senescence ( J:151908 )

• although mutant females display normal fertility and cycling at 2-3 months of age, they gradually lose fertility leading to near complete infertility by 6 months of age

decreased superovulation rate ( J:151908 )

• following induction of superovulation with PMSG and hCG, significantly fewer numbers of oocytes are retrieved from the oviducts of 6-mo-old mutant females than from age-matched wild-type control females (6 vs 22 oocytes, respectively)

• in contrast, only marginally smaller numbers of oocytes are retrieved at 2 months of age (20 vs 27 oocytes)

abnormal estrous cycle ( J:151908 )

• at 4 months of age or later, all mutant females display an irregular pattern of estrous cycles relative to age-matched control littermates

prolonged diestrus ( J:151908 )

• at 4- and 6 months of age, all mutant females exhibit a prolonged diestrous phase relative to age-matched control littermates

female infertility ( J:151908 )

• female mutants become infertile before they reach 6 months of age

growth/size/body

ovary cyst ( J:151908 )

• at 4 months of age, unstimulated mutant females display signs of hemorrhagic ovarian cysts; however, hemorrhagic cysts are significantly fewer than those observed in Esr1^tm1.1Mma females

endocrine/exocrine glands

ovary hemorrhage ( J:151908 )

• at 4 months of age, mutant females display signs of hemorrhagic ovarian cysts; however, hemorrhagic cysts are significantly fewer than those observed in Esr1^tm1.1Mma females

• following injection of PMSG alone or PMSG+hCG, mutant ovaries develop multiple hemorrhagic follicles, rarely observed in wild-type ovaries

increased gonadotroph cell number ( J:151908 )

• unexpectedly, at 4 months of age, mutant anterior pituitaries show a 2-fold increase in gonadotroph cell number relative to wild-type controls, with an approximately similar level of LH content in each cell

abnormal ovary morphology ( J:151908 )

• at 4 months of age, mutant ovaries display interstitial hypertrophy

decreased corpora lutea number ( J:151908 )

• at 4 months of age, mutant females display reduced numbers of corpora lutea relative to age-matched control females

abnormal ovarian follicle number ( J:151908 )

• at 4 months of age, mutant females exhibit increased numbers of late preantral and early antral stage follicles

abnormal theca cell layer morphology ( J:151908 )

increased theca cell number ( J:151908 )

• following induction of superovulation with PMSG +hCG injections, ovaries of 6-month-old mutant females are more heavily populated with theca (Cyp17-positive) cells than wild-type ovaries

• similarly, on the day of diestrus, ovaries of 4- and 10-month-old mutant females exhibit higher numbers of Cyp17-positive cells than wild-type ovaries

ovary cyst ( J:151908 )

• at 4 months of age, unstimulated mutant females display signs of hemorrhagic ovarian cysts; however, hemorrhagic cysts are significantly fewer than those observed in Esr1^tm1.1Mma females

homeostasis/metabolism

increased circulating testosterone level ( J:151908 )

• at 2- and 6-months of age, mutant females exhibit moderately increased basal levels of serum testosterone relative to wild-type control females

• in contrast, no significant differences in serum FSH or estradiol levels are observed

decreased circulating luteinizing hormone level ( J:151908 )

• in mutant females, serum LH levels are either markedly lower (2 months) or undetectable (6 months) relative to those in age-matched wild-type controls

nervous system

increased gonadotroph cell number ( J:151908 )

cardiovascular system

ovary hemorrhage ( J:151908 )

• at 4 months of age, mutant females display signs of hemorrhagic ovarian cysts; however, hemorrhagic cysts are significantly fewer than those observed in Esr1^tm1.1Mma females

• following injection of PMSG alone or PMSG+hCG, mutant ovaries develop multiple hemorrhagic follicles, rarely observed in wild-type ovaries

Allelic Composition	Map2k1^tm1Chrn/Map2k1^tm1Chrn Map2k2^tm1Chrn/Map2k2^tm1Chrn Tg(Cyp17a1-icre)AJako/0
Genetic Background	involves: 129/Sv * C57BL/6 * C57BL/6J * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Map2k1^tm1Chrn mutation (1 available); any Map2k1 mutation (94 available)
Map2k2^tm1Chrn mutation (1 available); any Map2k2 mutation (37 available)
Tg(Cyp17a1-icre)AJako mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

reproductive system phenotype ( J:278979 )

N	• males show no significant differences in testis weight, seminiferous tubule diameter, seminiferous epithelium morphology, expression of Sertoli and germ cell markers, total epididymal sperm count or sperm motility relative to control males

decreased seminal vesicle weight ( J:278979 )

• seminal vesicle weight is significantly reduced at P75 and P180

decreased Leydig cell number ( J:278979 )

• although an increase in Leydig cell numbers is observed up to ~P35, the total number of Leydig cells (Cyp11a1 positive cells) per testis is significantly reduced at all ages examined

• Leydig cell hypoplasia is accompanied by reduced testicular expression of several Leydig cell markers

decreased testes secretion ( J:278979 )

• in culture, primary Leydig cells from 50-day-old males show a drastic reduction in basal testosterone as well as severely impaired testosterone synthesis in response to stimulation with hCG (human choriogonadotropin), dibutyryl(Bt2)cAMP (a permeable cAMP analog), 22OHC (22-hydroxycholesterol) or P5 (pregnenolone)

• however, cAMP accumulation in response to hCG stimulation is normal

decreased litter size ( J:278979 )

• when males are paired with females of known fertility, the average number of pups/littler is significantly lower than that for control males (3.3 +/- 1.9 versus 6.5 +/- 0.6, respectively)

reduced male fertility ( J:278979 )

• male fertility starts to decline at ~3 months of age, and by 6 months the cumulative number of pups sired by males paired with fertile females is only ~50% of that sired by control males

• at the end of the 6-month mating period, the number of litters and number of pups/litter are significantly reduced relative to controls from 5.7 +/- 0.2 to 3.8 +/- 0.6 and from 6.2 +/- 0.3 to 4.8 +/- 0.5, respectively, while the number of days between litters is increased from 27 +/- 1 to 31 +/- 1

homeostasis/metabolism

abnormal circulating androgen level ( J:278979 )

• at P180, males exhibit several signs of hypoandrogenemia, including increased serum LH levels, reduced expression of two renal androgen-responsive genes, and decreased seminal vesicle weight relative to control males

increased circulating luteinizing hormone level ( J:278979 )

• serum LH levels are significantly increased at P180

abnormal testosterone level ( J:278979 )

• testicular extracts from 180-day-old males show a~40% reduction in intratesticular testosterone levels relative to controls

endocrine/exocrine glands

decreased seminal vesicle weight ( J:278979 )

• seminal vesicle weight is significantly reduced at P75 and P180

decreased Leydig cell number ( J:278979 )

• although an increase in Leydig cell numbers is observed up to ~P35, the total number of Leydig cells (Cyp11a1 positive cells) per testis is significantly reduced at all ages examined

• Leydig cell hypoplasia is accompanied by reduced testicular expression of several Leydig cell markers

decreased testes secretion ( J:278979 )

• however, cAMP accumulation in response to hCG stimulation is normal

behavior/neurological

decreased copulatory plug deposition ( J:278979 )

• when males are paired with females of known fertility, the number of vaginal plugs is significantly lower than that detected with control males

Allelic Composition	Bglap/Bglap2^tm3.1Kry/Bglap⁺ Gprc6a^tm1.1Kry/Gprc6a⁺ Tg(Cyp17a1-icre)AJako/0
Genetic Background	involves: C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bglap/Bglap2^tm3.1Kry mutation (0 available); any Bglap mutation (13 available)
Gprc6a^tm1.1Kry mutation (1 available); any Gprc6a mutation (67 available)
Tg(Cyp17a1-icre)AJako mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

oligozoospermia ( J:170888 )

decreased seminal vesicle weight ( J:170888 )

small testis ( J:170888 )

decreased testis weight ( J:170888 )

decreased epididymis weight ( J:170888 )

endocrine/exocrine glands

decreased seminal vesicle weight ( J:170888 )

small testis ( J:170888 )

decreased testis weight ( J:170888 )

cellular

oligozoospermia ( J:170888 )

Allelic Composition	Bglap/Bglap2^tm3.1Kry/Bglap2⁺ Gprc6a^tm1.1Kry/Gprc6a⁺ Tg(Cyp17a1-icre)AJako/0
Genetic Background	involves: C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bglap/Bglap2^tm3.1Kry mutation (0 available); any Bglap2 mutation (9 available)
Gprc6a^tm1.1Kry mutation (1 available); any Gprc6a mutation (67 available)
Tg(Cyp17a1-icre)AJako mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

oligozoospermia ( J:170888 )

decreased seminal vesicle weight ( J:170888 )

small testis ( J:170888 )

decreased testis weight ( J:170888 )

decreased epididymis weight ( J:170888 )

endocrine/exocrine glands

decreased seminal vesicle weight ( J:170888 )

small testis ( J:170888 )

decreased testis weight ( J:170888 )

cellular

oligozoospermia ( J:170888 )

Allelic Composition	Gprc6a^tm1.1Kry/Gprc6a^tm1.1Kry Tg(Cyp17a1-icre)AJako/0
Genetic Background	involves: C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gprc6a^tm1.1Kry mutation (1 available); any Gprc6a mutation (67 available)
Tg(Cyp17a1-icre)AJako mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

oligozoospermia ( J:170888 )

increased male germ cell apoptosis ( J:170888 )

decreased seminal vesicle weight ( J:170888 )

small testis ( J:170888 )

decreased testis weight ( J:170888 )

decreased epididymis weight ( J:170888 )

endocrine/exocrine glands

decreased seminal vesicle weight ( J:170888 )

small testis ( J:170888 )

decreased testis weight ( J:170888 )

cellular

oligozoospermia ( J:170888 )

increased male germ cell apoptosis ( J:170888 )

Allelic Composition	Bglap/Bglap2^tm3.1Kry/Bglap/Bglap2^tm3.1Kry Tg(Cyp17a1-icre)AJako/0
Genetic Background	involves: C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bglap/Bglap2^tm3.1Kry mutation (0 available); any Bglap2 mutation (9 available)
Tg(Cyp17a1-icre)AJako mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

reproductive system phenotype ( J:170888 )

N	• mice exhibit normal male normal reproductive system morphology

Allelic Composition	Bglap/Bglap2^tm3.1Kry/Bglap/Bglap2^tm3.1Kry Tg(Cyp17a1-icre)AJako/0
Genetic Background	involves: C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bglap/Bglap2^tm3.1Kry mutation (0 available); any Bglap mutation (13 available)
Tg(Cyp17a1-icre)AJako mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

reproductive system phenotype ( J:170888 )

N	• mice exhibit normal male normal reproductive system morphology

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