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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Adam17tm1Ckww
targeted mutation 1, Colin K W Watt
MGI:3807283
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Adam17tm1Ckww/Adam17tm1Ckww Not Specified MGI:3807372


Genotype
MGI:3807372
hm1
Allelic
Composition		 Adam17tm1Ckww/Adam17tm1Ckww
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adam17tm1Ckww mutation (0 available); any Adam17 mutation (64 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
mortality/aging ( J:138782 )
N
• mice are viable

immune system
abnormal dendritic cell physiology ( J:138782 )
• bone marrow derived dendritic cells fail to exhibit podosome disassembly in response to LPS- or Pam3CSK stimulation unlike in wild-type cells
• however, transfection of cells with an Adam17-expressing virus largely restores podosome disassembly




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory