Analysis Tools|
Allele Symbol Allele Name Allele ID |
Rbpjtm1.1Hon targeted mutation 1.1, Tasuku Honjo MGI:3807508 |
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| Summary |
6 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• retinas exhibit elevated vessel branching at P5
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• retinas exhibit elevated vessel branching at P5
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• tamoxifen-treated mice exhibit normal pancreatic ductal morphology and pancreata mass
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• tamoxifen-treated mice exhibit a decrease in YFP+ centroacinar cells compared with control mice
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• tamoxifen-treated mice exhibit an increase in YFP+ acinar cells compared with control mice
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• tamoxifen-treated mice exhibit a rapid transformation of YFP+ centroacinar cells into acinar cells compared with control mice
• however, tamoxifen-treated mice exhibit normal centroacinar and acinar cells proliferation and apoptosis
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• tamoxifen-treated mice exhibit a decrease in YFP+ centroacinar cells compared with control mice
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• tamoxifen-treated mice exhibit an increase in YFP+ acinar cells compared with control mice
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• tamoxifen-treated mice exhibit normal proliferation of YFP+ acinar cells
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• at E18.5, the respiratory epithelium was populated almost exclusively by Foxj1-expressing ciliated cells, unlike in control lungs where ciliated cells were interspersed with secretory Clara cells
• at E18.5, Ki67 labeling was dramatically reduced in large, medium and small airways, suggesting a severe decrease in epithelial cell proliferation relative to control lungs
• however, goblet cell fate was not lost, as shown by PAS and Alcian Blue staining of tracheal sections at birth (P0)
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• no secretory Clara cells were detected at E18.5, as determined by specific marker analysis
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• following treatment with tamoxifen, mice exhibit a reduction in the number of dILA neurons and an increased in the number of dILB neurons compared to in wild-type mice
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• there is a decrease in the thickness of the progenitor zone in the neural tube of E13.5 embryos when tamoxifen is given at E10.5
• tamoxifen induction at E10.5 leads to about a 50% reduction in dILA neurons in newborns and about a 50% increase in dILB neurons
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• following treatment with tamoxifen, mice exhibit a reduction in the number of dILA neurons compared to in wild-type mice
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• following treatment with tamoxifen, mice exhibit an increased in the number of dILB neurons compared to in wild-type mice
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• at E13.5 following treatment with tamoxifen, the progenitor domain is reduced compared to in wild-type mice
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• there is a decrease in the thickness of the progenitor zone in the neural tube of E13.5 embryos when tamoxifen is given at E10.5
• tamoxifen induction at E10.5 leads to about a 50% reduction in dILA neurons in newborns and about a 50% increase in dILB neurons
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• following treatment with tamoxifen, mice exhibit a reduction in the number of dILA neurons and an increased in the number of dILB neurons compared to in wild-type mice
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• retinas exhibit enhanced elevation in vessel branching at P5 than single Rbpj heterozygotes
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• retinas show greater extravascular fibrinogen staining and extravasation of perfused sulfo-NHS-LC-biotin, indicating greater impaired vascular integrity than single Eogt homozygotes
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• retinas exhibit enhanced elevation in vessel branching at P5 than single Rbpj heterozygotes
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 11/12/2024 MGI 6.24 |
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