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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Rsph1tm1Htan
targeted mutation 1, Hiromitsu Tanaka
MGI:3807704
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Rsph1tm1Htan/Rsph1tm1Htan involves: 129S1/Sv * C57BL/6J MGI:3807712
ht2
 		Rsph1tm1Htan/Rsph1+ involves: 129S1/Sv * C57BL/6J MGI:3807713


Genotype
MGI:3807712
hm1
Allelic
Composition		 Rsph1tm1Htan/Rsph1tm1Htan
Genetic
Background		 involves: 129S1/Sv * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rsph1tm1Htan mutation (1 available); any Rsph1 mutation (23 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype

Sperm are sparse or absent in Rsph1tm1Htan/Rsph1tm1Htan epididymides and sometimes have abnormal heads

growth/size/body
decreased body weight ( J:138122 )
• homozygous males with slightly smaller body mass
• homozygous females with normal body mass

reproductive system
reproductive system phenotype ( J:138122 )
N
• female fertility is normal
• adult males show normal seminiferous tubule characteristics and normal weights of testes and seminal vesicles
abnormal sperm flagellum morphology ( J:138122 )
• flagella containing an axoneme, mitochondria, outer dense fibers, and fibrous sheaths are formed; however, these components are disarranged in the cytoplasm
oligozoospermia ( J:138122 )
• sperm sparse or absent in epididymis
abnormal sperm head morphology ( J:138122 )
• step 15 spermatids show deformation of their heads
abnormal spermatid morphology ( J:138122 )
• step 15 spermatids show deformation of the heads and numerous vacuoles in the cytoplasm
increased Sertoli cell phagocytosis ( J:138122 )
• elongated spermatids phagocytosed by Sertoli cells
male infertility ( J:138122 )
• matings of males with wild-type females result in vaginal plugs but fail to lead to successful pregnancies
• nuclei from sperm of homozygous males capable of producing viable embryos

cellular
abnormal sperm flagellum morphology ( J:138122 )
• flagella containing an axoneme, mitochondria, outer dense fibers, and fibrous sheaths are formed; however, these components are disarranged in the cytoplasm
oligozoospermia ( J:138122 )
• sperm sparse or absent in epididymis
abnormal sperm head morphology ( J:138122 )
• step 15 spermatids show deformation of their heads
abnormal spermatid morphology ( J:138122 )
• step 15 spermatids show deformation of the heads and numerous vacuoles in the cytoplasm

homeostasis/metabolism
homeostasis/metabolism phenotype ( J:138122 )
N
• serum testosterone levels are normal




Genotype
MGI:3807713
ht2
Allelic
Composition		 Rsph1tm1Htan/Rsph1+
Genetic
Background		 involves: 129S1/Sv * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rsph1tm1Htan mutation (1 available); any Rsph1 mutation (23 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
growth/size/body
growth/size/body region phenotype ( J:138122 )
N
• heterozygous males show normal body mass

reproductive system
reproductive system phenotype ( J:138122 )
N
• heterozygous males are fertile




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
10/29/2024
MGI 6.24 		The Jackson Laboratory