Phenotypes associated with this allele

• Allele Symbol: Tg(KRT5-cre/ERT2)AJdg
• Allele Name: transgene insertion A, John DiGiovanni
• Allele ID: MGI:3807716
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Stat3^tm2Aki/Stat3^tm2Aki Tg(KRT5-cre/ERT2)AJdg/0	involves: 129P2/OlaHsd * FVB/N	MGI:3807776

Genotype
MGI:3807776

cn1

• Allelic Composition: Stat3^tm2Aki/Stat3^tm2Aki; Tg(KRT5-cre/ERT2)AJdg/0
• Genetic Background: involves: 129P2/OlaHsd * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

increased apoptosis ( J:138529 )

• DMBA causes increased apoptosis in the epidermis of skin where conditional disruption of Stat3 has been induced by Tamoxifen

neoplasm

decreased incidence of tumors by chemical induction ( J:138529 )

• tumor development after treatment with both DMBA and TPA was significantly reduced in mice deficient in Stat3 expression as a result of tamoxifen treatment

• tamoxifen induced disruption of Stat3 inhibits growth of pre existing papillomas

integument

abnormal epidermal layer morphology ( J:138529 )

• reduced TPA induced epidermal proliferation after Stat3 disrutption mediated by tamoxifen

homeostasis/metabolism

decreased incidence of tumors by chemical induction ( J:138529 )

• tumor development after treatment with both DMBA and TPA was significantly reduced in mice deficient in Stat3 expression as a result of tamoxifen treatment

• tamoxifen induced disruption of Stat3 inhibits growth of pre existing papillomas