All Phenotypes Pth2<tm1Vlcg> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Pth2^tm1Vlcg
targeted mutation 1, Velocigene
MGI:3807987

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Pth2^tm1Vlcg/Pth2^tm1Vlcg	involves: 129 * C57BL/6	MGI:3808007
cn2	Pth2^tm1Vlcg/Pth2^tm1Vlcg Tg(CAG-LacZ,-Pth2)1Tbu/0 Tg(Prm-cre)58Og/0	involves: 129 * C57BL/6	MGI:3808008

Allelic Composition	Pth2^tm1Vlcg/Pth2^tm1Vlcg
Genetic Background	involves: 129 * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pth2^tm1Vlcg mutation (0 available); any Pth2 mutation (4 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

abnormal reproductive system morphology ( J:138142 )

abnormal spermatid morphology ( J:138142 )

• complete absence of spermatids in testes

• widespread apoptotic cell death in testes

• early stage spermatocytes and spermatogonia persist

abnormal meiosis ( J:138142 )

• homologous synapsis is incomplete in first prophase

abnormal female reproductive system morphology ( J:138142 )

absent ovarian follicles ( J:138142 )

small ovary ( J:138142 )

• atretic ovaries

abnormal male reproductive system morphology ( J:138142 )

decreased seminal vesicle weight ( J:138142 )

• slight reduction

abnormal testis morphology ( J:138142 )

small testis ( J:138142 )

• half normal length at 80-90 days

decreased testis weight ( J:138142 )

• 1/4 normal weight at 70-80 days

infertility ( J:138142 )

female infertility ( J:138142 )

male infertility ( J:138142 )

endocrine/exocrine glands

decreased seminal vesicle weight ( J:138142 )

• slight reduction

absent ovarian follicles ( J:138142 )

small ovary ( J:138142 )

• atretic ovaries

abnormal testis morphology ( J:138142 )

small testis ( J:138142 )

• half normal length at 80-90 days

decreased testis weight ( J:138142 )

• 1/4 normal weight at 70-80 days

cellular

abnormal spermatid morphology ( J:138142 )

• complete absence of spermatids in testes

• widespread apoptotic cell death in testes

• early stage spermatocytes and spermatogonia persist

abnormal meiosis ( J:138142 )

• homologous synapsis is incomplete in first prophase

Allelic Composition	Pth2^tm1Vlcg/Pth2^tm1Vlcg Tg(CAG-LacZ,-Pth2)1Tbu/0 Tg(Prm-cre)58Og/0
Genetic Background	involves: 129 * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pth2^tm1Vlcg mutation (0 available); any Pth2 mutation (4 available)
Tg(CAG-LacZ,-Pth2)1Tbu mutation (0 available)
Tg(Prm-cre)58Og mutation (4 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

reproductive system phenotype ( J:138142 )

N	• male fertility is restored

female infertility ( J:138142 )

• persists

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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