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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Pth2tm1Vlcg
targeted mutation 1, Velocigene
MGI:3807987
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Pth2tm1Vlcg/Pth2tm1Vlcg involves: 129 * C57BL/6 MGI:3808007
cn2
Pth2tm1Vlcg/Pth2tm1Vlcg
Tg(CAG-LacZ,-Pth2)1Tbu/0
Tg(Prm-cre)58Og/0
involves: 129 * C57BL/6 MGI:3808008


Genotype
MGI:3808007
hm1
Allelic
Composition
Pth2tm1Vlcg/Pth2tm1Vlcg
Genetic
Background
involves: 129 * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pth2tm1Vlcg mutation (0 available); any Pth2 mutation (4 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
reproductive system
• complete absence of spermatids in testes
• widespread apoptotic cell death in testes
• early stage spermatocytes and spermatogonia persist
• homologous synapsis is incomplete in first prophase
• atretic ovaries
• half normal length at 80-90 days
• 1/4 normal weight at 70-80 days

endocrine/exocrine glands
• atretic ovaries
• half normal length at 80-90 days
• 1/4 normal weight at 70-80 days

cellular
• complete absence of spermatids in testes
• widespread apoptotic cell death in testes
• early stage spermatocytes and spermatogonia persist
• homologous synapsis is incomplete in first prophase




Genotype
MGI:3808008
cn2
Allelic
Composition
Pth2tm1Vlcg/Pth2tm1Vlcg
Tg(CAG-LacZ,-Pth2)1Tbu/0
Tg(Prm-cre)58Og/0
Genetic
Background
involves: 129 * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pth2tm1Vlcg mutation (0 available); any Pth2 mutation (4 available)
Tg(CAG-LacZ,-Pth2)1Tbu mutation (0 available)
Tg(Prm-cre)58Og mutation (4 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
reproductive system
N
• male fertility is restored
• persists





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
12/10/2024
MGI 6.24
The Jackson Laboratory