Phenotypes associated with this allele

• Allele Symbol: Tnfrsf1a^tm1Rsie
• Allele Name: targeted mutation 1, Richard M Siegel
• Allele ID: MGI:3808000
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Tnfrsf1a^tm1Rsie/Tnfrsf1a^tm1Rsie	B6.Cg-Tnfrsf1a^tm1Rsie	MGI:4461166
ht2	Tnfrsf1a^tm1Rsie/Tnfrsf1a^+	B6.Cg-Tnfrsf1a^tm1Rsie	MGI:4461165

Genotype
MGI:4461166

hm1

• Allelic Composition: Tnfrsf1a^tm1Rsie/Tnfrsf1a^tm1Rsie
• Genetic Background: B6.Cg-Tnfrsf1a^tm1Rsie

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

decreased susceptibility to induced morbidity/mortality ( J:160543 )

• mice treated with LPS and D-galactosamine fail to exhibit induced mortality unlike similarly treated wild-type mice

immune system

abnormal macrophage physiology ( J:160543 )

• TNF-stimulated peritoneal macrophages produce less IL6 and CXCL2 (MIP2) than similarly treated wild-type cells

decreased circulating interleukin-1 beta level ( J:160543 )

• following LPS challenge

decreased circulating interleukin-6 level ( J:160543 )

• following LPS challenge

increased circulating tumor necrosis factor level ( J:160543 )

• following LPS challenge

abnormal follicular dendritic cell morphology ( J:160543 )

• mice lack an intact follicular dendritic cell network and defined B- and T-cell zones unlike in wild-type mice

abnormal chemokine secretion ( J:160543 )

• TNF-stimulated peritoneal macrophages produce less CXCL2 (MIP2) than similarly treated wild-type cells

decreased interleukin-6 secretion ( J:160543 )

• TNF-stimulated peritoneal macrophages produce less IL6 than similarly treated wild-type cells

decreased susceptibility to endotoxin shock ( J:160543 )

• LPS-treated mice exhibit a somewhat blunted acute hypothermic response compared with similarly treated wild-type mice

• mice treated with LPS and D-galactosamine fail to exhibit induced mortality unlike similarly treated wild-type mice

homeostasis/metabolism

decreased circulating interleukin-1 beta level ( J:160543 )

• following LPS challenge

decreased circulating interleukin-6 level ( J:160543 )

• following LPS challenge

increased circulating tumor necrosis factor level ( J:160543 )

• following LPS challenge

hematopoietic system

abnormal macrophage physiology ( J:160543 )

• TNF-stimulated peritoneal macrophages produce less IL6 and CXCL2 (MIP2) than similarly treated wild-type cells

Genotype
MGI:4461165

ht2

• Allelic Composition: Tnfrsf1a^tm1Rsie/Tnfrsf1a⁺
• Genetic Background: B6.Cg-Tnfrsf1a^tm1Rsie

mortality/aging

increased susceptibility to induced morbidity/mortality ( J:160543 )

• mice treated with 5 ng/g LPS and D-galactosamine exhibit increased mortality unlike similarly treated wild-type mice

• however, mortality at 10 ng/g LPS and D-galactosamine is normal

immune system

increased circulating tumor necrosis factor level ( J:160543 )

• following LPS challenge

increased interleukin-6 secretion ( J:160543 )

• LPS-stimulated mouse embryonic fibroblasts exhibit increased IL6 secretion that is enhanced by application of TNFR2-Fc compared with similarly treated wild-type cells

increased susceptibility to endotoxin shock ( J:160543 )

• mice treated with LPS and D-galactosamine exhibit increased mortality unlike similarly treated wild-type mice

• however, mortality at 10 ng/g LPS and D-galactosamine is normal

• LPS-treated mice exhibit exaggerated and prolonged temperature drop compared with similarly treated wild-type mice

homeostasis/metabolism

impaired adaptive thermogenesis ( J:160543 )

• LPS-treated mice exhibit exaggerated and prolonged temperature drop compared with similarly treated wild-type mice

increased circulating tumor necrosis factor level ( J:160543 )

• following LPS challenge

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
autosomal dominant familial periodic fever		DOID:0090018	OMIM:142680	J:160543