Phenotypes associated with this allele

• Allele Symbol: Tbx4^tm1.1Kng
• Allele Name: targeted mutation 1.1, David M Kingsley
• Allele ID: MGI:3808010
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Tbx4^tm1.1Kng/Tbx4^tm1.1Kng	involves: 129P2/OlaHsd * C57BL/6J * DBA/2	MGI:3808020
ht2	Tbx4^tm1.1Kng/Tbx4^+	involves: 129P2/OlaHsd * C57BL/6J * DBA/2	MGI:3808021

Genotype
MGI:3808020

hm1

• Allelic Composition: Tbx4^tm1.1Kng/Tbx4^tm1.1Kng
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * DBA/2

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

limbs/digits/tail

limbs/digits/tail phenotype ( J:139169 )

N • despite abnormal hindlimbs, forelimb morphology and development are normal

brachydactyly ( J:139169 )

• anterior hindlimb digits are more severely reduced than posterior hindlimb digits compared to in wild-type mice with distal elements more reduced than proximal ones

fused tarsal bones ( J:139169 )

short femur ( J:139169 )

abnormal fibula morphology ( J:139169 )

• fibulas lack the peroneal process in all mice

short tibia ( J:139169 )

abnormal patella morphology ( J:139169 )

• patellas are shorter than in wild-type mice

patellar dislocation ( J:139169 )

• 33% of mice exhibit a displaced patella

abnormal limb development ( J:139169 )

• at E11.5, hindlimbs are 7% narrower than in wild-type mice

• however, forelimb development is normal

skeleton

fused tarsal bones ( J:139169 )

short femur ( J:139169 )

abnormal fibula morphology ( J:139169 )

• fibulas lack the peroneal process in all mice

short tibia ( J:139169 )

abnormal patella morphology ( J:139169 )

• patellas are shorter than in wild-type mice

patellar dislocation ( J:139169 )

• 33% of mice exhibit a displaced patella

abnormal pelvic girdle bone morphology ( J:139169 )

• pelvic width is reduced compared to in wild-type mice

Genotype
MGI:3808021

ht2

• Allelic Composition: Tbx4^tm1.1Kng/Tbx4⁺
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * DBA/2

limbs/digits/tail

brachydactyly ( J:139169 )

• anterior hindlimb digits are more severely reduced than posterior hindlimb digits compared to in wild-type mice with distal elements more reduced than proximal ones

short femur ( J:139169 )

• mice exhibit short femurs compared to wild-type mice but not as short as in homozygotes

short tibia ( J:139169 )

• mice exhibit short tibias compared to wild-type mice but not as short as in homozygotes

abnormal patella morphology ( J:139169 )

• patellas are shorter than in wild-type mice but not as short as in homozygotes

skeleton

short femur ( J:139169 )

• mice exhibit short femurs compared to wild-type mice but not as short as in homozygotes

short tibia ( J:139169 )

• mice exhibit short tibias compared to wild-type mice but not as short as in homozygotes

abnormal patella morphology ( J:139169 )

• patellas are shorter than in wild-type mice but not as short as in homozygotes

abnormal pelvic girdle bone morphology ( J:139169 )

• pelvic width is reduced compared to in wild-type mice but not as severely as in homozygotes