All Phenotypes Hes1<tm1Kag> MGI Mouse

About Help FAQ

Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Hes1^tm1Kag
targeted mutation 1, Ryoichiro Kageyama
MGI:3808031

Summary

5 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Hes1^tm1Kag/Hes1^tm1Kag Hes3^tm1Kag/Hes3^tm1Kag Hes5^tm1Fgu/Hes5^tm1Fgu Tg(Nes-cre/ERT2)5-1Imayo/0	involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA	MGI:3808127
cn2	Emx1^tm1(cre)Ito/Emx1⁺ Hes1^tm1Kag/Hes1^tm1Kag Hes3^tm1Kag/Hes3^tm1Kag Hes5^tm1Fgu/Hes5^tm1Fgu	involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA	MGI:3808125
cn3	Hes1^tm1Kag/Hes1^tm1Kag Foxa2^{tm3.1(icre)Heli}/Foxa2⁺	involves: 129P2/OlaHsd * C57BL/6 * CBA	MGI:5428766
cn4	Emx1^tm1(cre)Ito/Emx1⁺ Hes1^tm1Kag/Hes1^tm1Kag	involves: 129P2/OlaHsd * C57BL/6 * CBA	MGI:3808124
cn5	Alb^{tm1(cre/ERT2)Mtz}/Alb⁺ Hes1^tm1Kag/Hes1^tm1Kag	involves: 129S2/SvPas * C57BL/6 * CBA	MGI:5506744

Allelic Composition	Hes1^tm1Kag/Hes1^tm1Kag Hes3^tm1Kag/Hes3^tm1Kag Hes5^tm1Fgu/Hes5^tm1Fgu Tg(Nes-cre/ERT2)5-1Imayo/0
Genetic Background	involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hes1^tm1Kag mutation (2 available); any Hes1 mutation (23 available)
Hes3^tm1Kag mutation (2 available); any Hes3 mutation (18 available)
Hes5^tm1Fgu mutation (1 available); any Hes5 mutation (16 available)
Tg(Nes-cre/ERT2)5-1Imayo mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

nervous system phenotype ( J:139170 )

N	• mice exhibit no change in Cajal-Retzius cell number

Allelic Composition	Emx1^tm1(cre)Ito/Emx1⁺ Hes1^tm1Kag/Hes1^tm1Kag Hes3^tm1Kag/Hes3^tm1Kag Hes5^tm1Fgu/Hes5^tm1Fgu
Genetic Background	involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Emx1^tm1(cre)Ito mutation (1 available); any Emx1 mutation (34 available)
Hes1^tm1Kag mutation (2 available); any Hes1 mutation (23 available)
Hes3^tm1Kag mutation (2 available); any Hes3 mutation (18 available)
Hes5^tm1Fgu mutation (1 available); any Hes5 mutation (16 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal neuron differentiation ( J:139170 )

• mice exhibit accelerated differentiation of neurons compared to in wild-type mice, including Cajal-Retzius cells in the dorsal telencephalon

abnormal embryonic neuroepithelium morphology ( J:139170 )

• unlike in wild-type mice, at E11.5 and E12.5 dorsal midline cells do not flatten and remain pseudostratified

abnormal brain morphology ( J:139170 )

• mice exhibit mild abnormalities in the cortical hem and cortical neuroepithelium

increased Cajal-Retzius cell number ( J:139170 )

• at E11.5 and E12.5, the number of Cajal-Retzius cells in the marginal zone of the piriform cortex is increased compared to in wild-type mice

absent choroid plexus ( J:139170 )

embryo

abnormal embryonic neuroepithelium morphology ( J:139170 )

• unlike in wild-type mice, at E11.5 and E12.5 dorsal midline cells do not flatten and remain pseudostratified

cellular

abnormal neuron differentiation ( J:139170 )

• mice exhibit accelerated differentiation of neurons compared to in wild-type mice, including Cajal-Retzius cells in the dorsal telencephalon

Allelic Composition	Hes1^tm1Kag/Hes1^tm1Kag Foxa2^{tm3.1(icre)Heli}/Foxa2⁺
Genetic Background	involves: 129P2/OlaHsd * C57BL/6 * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Foxa2^{tm3.1(icre)Heli} mutation (0 available); any Foxa2 mutation (28 available)
Hes1^tm1Kag mutation (2 available); any Hes1 mutation (23 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

endocrine/exocrine glands

abnormal pancreas development ( J:184814 )

• embryos show an increase in Neurog3+ve cells at E9.5; by E10.5, an increase in glucagon+ve cells is seen

• at E15.5, the insulin +ve area of the pancreatic tissue is reduced by 65% compared to control embryos similar to the dnMaml-expressing embryos

• some DBA+ve cells are observed in E18.5 embryos

• proximal-distal patterning is altered in the embryonic pancreas; at E15.5, Nkx6-1+ve, Ptf1a-ve cells are reduced in the proximal domain by 85% while Hnf1b and DBA+ve cells are reduced in number with a concurrent increase in Nkx6-1-ve, Ptf1a+ve cells as well as Cpa+ve and amylase +ve cells

• Nkx6-1 and Ptf1a double-positive cells are observed in significant numbers

• at E12.5, Nkx6-1+ve Ptf1a-ve are present, but reduced in numbers by 50% compared to controls along with no increase in Nkx6-1-ve Ptf1a+ve cells

abnormal pancreatic beta cell differentiation ( J:184814 )

• at E15.5, the insulin +ve area of the pancreatic tissue is reduced by 65% compared to control embryos

cellular

abnormal pancreatic beta cell differentiation ( J:184814 )

• at E15.5, the insulin +ve area of the pancreatic tissue is reduced by 65% compared to control embryos

Allelic Composition	Emx1^tm1(cre)Ito/Emx1⁺ Hes1^tm1Kag/Hes1^tm1Kag
Genetic Background	involves: 129P2/OlaHsd * C57BL/6 * CBA

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

nervous system phenotype ( J:139170 )

N	• mice exhibit normal telencephalon development

Allelic Composition	Alb^{tm1(cre/ERT2)Mtz}/Alb⁺ Hes1^tm1Kag/Hes1^tm1Kag
Genetic Background	involves: 129S2/SvPas * C57BL/6 * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Alb^{tm1(cre/ERT2)Mtz} mutation (2 available); any Alb mutation (97 available)
Hes1^tm1Kag mutation (2 available); any Hes1 mutation (23 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

neoplasm ( J:192740 )

N	• after 14 weeks of tamoxifen administration, neoplastic nodules are not found in livers of mice; intrahepatic cholangiocarcinoma (ICC) does not develop in absence of Notch1- mediated conversion of hepatocytes into biliary lineage cells

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24