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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tax1bp1tm1Ktj
targeted mutation 1, Kuan-Teh Jeang
MGI:3808042
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Tax1bp1tm1Ktj/Tax1bp1tm1Ktj B6.129P2-Tax1bp1tm1Ktj MGI:3810389


Genotype
MGI:3810389
hm1
Allelic
Composition
Tax1bp1tm1Ktj/Tax1bp1tm1Ktj
Genetic
Background
B6.129P2-Tax1bp1tm1Ktj
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tax1bp1tm1Ktj mutation (0 available); any Tax1bp1 mutation (38 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• significantly reduced survival by 18 months

growth/size/body
• fail to thrive after birth
• grow considerably more slowly than controls

cardiovascular system
• all mice that die prematurely have grossly hypertrophic cardiac valve leaflets with cellular infiltration and collagen invasion
• dramatically thickened valve leaflets
• not seen in newborns and young mice through 21 days of age
• all mice that die prematurely show severe hypertrophic valvulitis with infiltrations of T cells and macrophages in the cardiac valves

immune system
• all mice that die prematurely show severe hypertrophic valvulitis with infiltrations of T cells and macrophages in the cardiac valves
• involved in skin infiltration
• involved in skin infiltration
• involved in skin infiltration
• hypersensitivity to injected TNF alpha and IL1 beta
• elevated in heart tissues
• elevated in heart tissues
• elevated in heart tissues
• skin inflammation that is refractory to treatment is prevalent

integument
• skin inflammation that is refractory to treatment is prevalent

cellular
• involved in skin infiltration

hematopoietic system
• involved in skin infiltration
• involved in skin infiltration
• involved in skin infiltration





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/19/2024
MGI 6.24
The Jackson Laboratory