mortality/aging
• significantly reduced survival by 18 months
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growth/size/body
• fail to thrive after birth
• grow considerably more slowly than controls
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cardiovascular system
• all mice that die prematurely have grossly hypertrophic cardiac valve leaflets with cellular infiltration and collagen invasion
• dramatically thickened valve leaflets
• not seen in newborns and young mice through 21 days of age
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• all mice that die prematurely show severe hypertrophic valvulitis with infiltrations of T cells and macrophages in the cardiac valves
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immune system
• all mice that die prematurely show severe hypertrophic valvulitis with infiltrations of T cells and macrophages in the cardiac valves
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• involved in skin infiltration
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• involved in skin infiltration
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• involved in skin infiltration
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• hypersensitivity to injected TNF alpha and IL1 beta
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• elevated in heart tissues
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• elevated in heart tissues
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• elevated in heart tissues
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• skin inflammation that is refractory to treatment is prevalent
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integument
• skin inflammation that is refractory to treatment is prevalent
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cellular
• involved in skin infiltration
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hematopoietic system
• involved in skin infiltration
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• involved in skin infiltration
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• involved in skin infiltration
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