Phenotypes associated with this allele

• Allele Symbol: Tal1^tm1Por
• Allele Name: targeted mutation 1, Catherine Porcher
• Allele ID: MGI:3808120
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Tal1^tm1Por/Tal1^tm1Por	involves: 129P2/OlaHsd	MGI:3808147

Genotype
MGI:3808147

hm1

• Allelic Composition: Tal1^tm1Por/Tal1^tm1Por
• Genetic Background: involves: 129P2/OlaHsd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

decreased survivor rate ( J:139179 )

• only 5% of homozygotes live until birth

lethality throughout fetal growth and development, incomplete penetrance ( J:139179 )

• embryonic lethality occurs to 80% of homozygotes

• the first dead embryos are found at E14.5 and the numbers increase until E17.5

• embryonic death that occurs after E14 is in marked contrast to Tal1 null homozygotes that die at E9.5

embryo

decreased embryo size ( J:139179 )

• surviving mutant embryos are smaller than controls starting at E14.5

pale yolk sac ( J:139179 )

• yolk sacs are pale compared to controls at E9.5

abnormal embryonic erythropoiesis ( J:139179 )

• blood from E9.5 embryos lack mature basophilic erythroblasts and instead have immature proerythroblasts

• colonies derived from erythroid progenitors isolated from E8.5 yolk sacs contain fewer fully differentiated red blood cells than in controls

• similar in vitro results are obtained from E14.5 livers are used as a source for erythroid progenitors

• E14.5 embryos are paler than controls and have fewer enucleated erthyrocytes in circulation than controls

growth/size/body

decreased embryo size ( J:139179 )

• surviving mutant embryos are smaller than controls starting at E14.5

increased spleen weight ( J:139179 )

• spleen of mice average 346 grams compared to 131 grams in controls

hematopoietic system

abnormal embryonic erythropoiesis ( J:139179 )

• blood from E9.5 embryos lack mature basophilic erythroblasts and instead have immature proerythroblasts

• colonies derived from erythroid progenitors isolated from E8.5 yolk sacs contain fewer fully differentiated red blood cells than in controls

• similar in vitro results are obtained from E14.5 livers are used as a source for erythroid progenitors

• E14.5 embryos are paler than controls and have fewer enucleated erthyrocytes in circulation than controls

increased spleen weight ( J:139179 )

• spleen of mice average 346 grams compared to 131 grams in controls

abnormal erythropoiesis ( J:139179 )

extramedullary hematopoiesis ( J:139179 )

• occurs in the spleen with an increase in the number of red blood cells that are CD71⁺Ter119⁺

microcytic anemia ( J:139179 )

• adult mice have mild microcytic anemia

abnormal erythroid progenitor cell morphology ( J:139179 )

• CFU-Es cultured in vitro become poorly hemoglobinized and lack markers of mature erythrocytes

decreased hematocrit ( J:139179 )

• hematocrit of adults is reduced by around 18%

decreased hemoglobin content ( J:139179 )

• hemoglobin content in adults is decreased from 17.12 g/dL to 13.57 g/dL

decreased mean corpuscular hemoglobin concentration ( J:139179 )

• mean corpuscular hemoglobin in adults is significantly reduced from 17.0 pg to 13.27 pg

decreased mean corpuscular volume ( J:139179 )

• decreased mean corpuscular volume in adults is reduced by almost 20% compared to controls

increased red blood cell distribution width ( J:139179 )

• an increase in red blood cell distribution width is noted

anisocytosis ( J:139179 )

• is observed in adults with an increase in red cell distribution width

immune system

increased spleen weight ( J:139179 )

• spleen of mice average 346 grams compared to 131 grams in controls