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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tg(FOXJ1-cre/ERT2)1Blh
transgene insertion 1, Brigid L Hogan
MGI:3808149
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Kif3atm1Gsn/Kif3atm2Gsn
Tg(FOXJ1-cre/ERT2)1Blh/0 		involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA MGI:5285557
cn2
 		Foxj1tm1.1Ctk/Foxj1tm1.2Ctk
Tg(FOXJ1-cre/ERT2)1Blh/0 		involves: C57BL/6 * DBA MGI:5285554


Genotype
MGI:5285557
cn1
Allelic
Composition		 Kif3atm1Gsn/Kif3atm2Gsn
Tg(FOXJ1-cre/ERT2)1Blh/0
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kif3atm1Gsn mutation (1 available); any Kif3a mutation (33 available)
Kif3atm2Gsn mutation (1 available); any Kif3a mutation (33 available)
Tg(FOXJ1-cre/ERT2)1Blh mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal brain morphology ( J:174694 )
• tamoxifen-treated mice lack multiciliated maturing ependymal cells unlike in wild-type mice
• however, monociliated cells are observed




Genotype
MGI:5285554
cn2
Allelic
Composition		 Foxj1tm1.1Ctk/Foxj1tm1.2Ctk
Tg(FOXJ1-cre/ERT2)1Blh/0
Genetic
Background		 involves: C57BL/6 * DBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Foxj1tm1.1Ctk mutation (0 available); any Foxj1 mutation (21 available)
Foxj1tm1.2Ctk mutation (0 available); any Foxj1 mutation (21 available)
Tg(FOXJ1-cre/ERT2)1Blh mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal neuron differentiation ( J:174694 )
• mice injected with tamoxifen at P14 exhibit defective coverage of the ventricular wall with neuroblast chains compared to in control mice
abnormal rostral migratory stream morphology ( J:174694 )
• at P28, mice injected with tamoxifen at P14 exhibit decreased rostral migratory stream cellularity/size compared with control mice
hydrocephaly ( J:174694 )
• in some mice injected with tamoxifen at P14

cellular
abnormal neuron differentiation ( J:174694 )
• mice injected with tamoxifen at P14 exhibit defective coverage of the ventricular wall with neuroblast chains compared to in control mice




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory