About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tg(FOXJ1-cre/ERT2)1Blh
transgene insertion 1, Brigid L Hogan
MGI:3808149
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Kif3atm1Gsn/Kif3atm2Gsn
Tg(FOXJ1-cre/ERT2)1Blh/0 		involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA MGI:5285557
cn2
 		Foxj1tm1.1Ctk/Foxj1tm1.2Ctk
Tg(FOXJ1-cre/ERT2)1Blh/0 		involves: C57BL/6 * DBA MGI:5285554


Genotype
MGI:5285557
cn1
Allelic
Composition		 Kif3atm1Gsn/Kif3atm2Gsn
Tg(FOXJ1-cre/ERT2)1Blh/0
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kif3atm1Gsn mutation (1 available); any Kif3a mutation (33 available)
Kif3atm2Gsn mutation (1 available); any Kif3a mutation (33 available)
Tg(FOXJ1-cre/ERT2)1Blh mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal brain morphology ( J:174694 )
• tamoxifen-treated mice lack multiciliated maturing ependymal cells unlike in wild-type mice
• however, monociliated cells are observed




Genotype
MGI:5285554
cn2
Allelic
Composition		 Foxj1tm1.1Ctk/Foxj1tm1.2Ctk
Tg(FOXJ1-cre/ERT2)1Blh/0
Genetic
Background		 involves: C57BL/6 * DBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Foxj1tm1.1Ctk mutation (0 available); any Foxj1 mutation (21 available)
Foxj1tm1.2Ctk mutation (0 available); any Foxj1 mutation (21 available)
Tg(FOXJ1-cre/ERT2)1Blh mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal neuron differentiation ( J:174694 )
• mice injected with tamoxifen at P14 exhibit defective coverage of the ventricular wall with neuroblast chains compared to in control mice
abnormal rostral migratory stream morphology ( J:174694 )
• at P28, mice injected with tamoxifen at P14 exhibit decreased rostral migratory stream cellularity/size compared with control mice
hydrocephaly ( J:174694 )
• in some mice injected with tamoxifen at P14

cellular
abnormal neuron differentiation ( J:174694 )
• mice injected with tamoxifen at P14 exhibit defective coverage of the ventricular wall with neuroblast chains compared to in control mice




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory