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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Egflamtm1Tfir
targeted mutation 1, Takahisa Furukawa
MGI:3808156
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Egflamtm1Tfir/Egflamtm1Tfir involves: 129S6/SvEvTac MGI:3808158


Genotype
MGI:3808158
hm1
Allelic
Composition		 Egflamtm1Tfir/Egflamtm1Tfir
Genetic
Background		 involves: 129S6/SvEvTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Egflamtm1Tfir mutation (1 available); any Egflam mutation (60 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal retina cone cell morphology ( J:138693 )
• absence of the tips of the bipolar cell dendrites in cone ribbon synapses
abnormal retina rod cell morphology ( J:138693 )
• absence of the tips of the bipolar cell dendrites in rod ribbon synapses

vision/eye
abnormal retina cone cell morphology ( J:138693 )
• absence of the tips of the bipolar cell dendrites in cone ribbon synapses
abnormal retina rod cell morphology ( J:138693 )
• absence of the tips of the bipolar cell dendrites in rod ribbon synapses
abnormal eye physiology ( J:138693 )
• sensitivity to small angle stripes was significantly impaired in the optokinetic responses
abnormal cone electrophysiology ( J:138693 )
• the signal transmission from the cone photoreceptor to the cone bipolar cell is impaired
abnormal rod electrophysiology ( J:138693 )
• the signal transmission from the rod photoreceptor to the rod bipolar cell is less sensitive and is delayed




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory