Analysis Tools
nervous system
| N |
• mice exhibit normal monoamine neurotransmitter levels and turnover
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• elevated ratio of AMPAR to NMDAR components
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• increased spine density in glutamatergic neurons in the layers 2/3 of the prelimbic prefrontal cortex
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• increased spine density in glutamatergic neurons in the layers 2/3 of the prelimbic prefrontal cortex
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• increased frequency in glutamatergic neurons in the layers 2/3 of the prelimbic prefrontal cortex
• however, amplitude and paired-pulse ratio are normal
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• elevated amplitude
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behavior/neurological
| N |
• mice exhibit normal locomotor activity, habituation, motor coordination and learning
• female mice exhibit anxiolytic phenotype similar to male mice
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• male mice exhibit reduced immobility when suspended by the tail or in a forced swim test compared with wild-type mice
• female mice exhibit anti-depressant-like phenotype similar to male mice
• mice subjected to unpredictable chronic mild stress exhibit resiliency to chronic stress and resistance to stress-induced anhedonia compared with wild-type mice
• however, treatment with an AMPAR blocker (NBQX) reverted antidepressant-like phenotypes
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• male mice bury fewer marbles and spend more time in the open arms of an elevated plus maze compared with wild-type mice
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homeostasis/metabolism
