Analysis Tools
reproductive system
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• seminal vesicle glands continue to grow as mice age and show pathologic changes, including regions of necrosis and hemorrhage
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• seminal vesicles are significantly enlarged in adult males
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• seminal vesicle-to-body weight ratio is significantly increased in adult males
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• adult testes exhibit significantly more seminiferous tubules per cross-section
• however, seminiferous tubule diameter and ratio of stage VIII to the total numbers of seminiferous tubules per cross-sectional area remain normal
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• Leydig cells retain their ability to proliferate and functionally generate a hyperandrogenic condition
• an indicator of adult Leydig cells, Hsd3b6, fails to show the expected developmental increase in adult testes
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• adult testes are significantly enlarged
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• testicular interstitial compartments are significantly expanded and contain more MKI67+ cells than wild-type testes
• several Leydig cell progenitor-associated transcripts remain elevated in adult testes
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• testis-to-body weight ratio is significantly increased in adult males
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• serum testosterone levels are significantly increased, androgen-responsive tissues are hyperstimulated, and sperm production is significantly greater than in wild-type males
• testis hyperfunctionality is driven by altered developmental maturation of Leydig cells
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• total sperm count is significantly increased in adult males
• however, sperm exhibit normal patterns of motility
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• precocial development of the scrotal region at time of weaning (P21)
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• females are subfertile; only 58% mated during cohabitation with wild- type males and only 57% of the seminal plug-positive females were pregnant on gestation day 9.5
• however, male fertility is relatively normal
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homeostasis/metabolism
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• serum testosterone levels are significantly increased in adult males
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• serum LH levels are significantly increased in adult males
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endocrine/exocrine glands
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• seminal vesicle glands continue to grow as mice age and show pathologic changes, including regions of necrosis and hemorrhage
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|
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• seminal vesicles are significantly enlarged in adult males
|
|
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• seminal vesicle-to-body weight ratio is significantly increased in adult males
|
|
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• adult testes exhibit significantly more seminiferous tubules per cross-section
• however, seminiferous tubule diameter and ratio of stage VIII to the total numbers of seminiferous tubules per cross-sectional area remain normal
|
|
|
• Leydig cells retain their ability to proliferate and functionally generate a hyperandrogenic condition
• an indicator of adult Leydig cells, Hsd3b6, fails to show the expected developmental increase in adult testes
|
|
|
• adult testes are significantly enlarged
|
|
|
• testicular interstitial compartments are significantly expanded and contain more MKI67+ cells than wild-type testes
• several Leydig cell progenitor-associated transcripts remain elevated in adult testes
|
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• testis-to-body weight ratio is significantly increased in adult males
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• Lhb (luteinizing hormone beta) mRNA levels are significantly increased whereas Fshb (follicle stimulating hormone beta) mRNA levels are significantly reduced in the pituitary of adult males
• however, serum FSH levels are normal in adult males
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• serum testosterone levels are significantly increased, androgen-responsive tissues are hyperstimulated, and sperm production is significantly greater than in wild-type males
• testis hyperfunctionality is driven by altered developmental maturation of Leydig cells
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growth/size/body
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• body weight is significantly increased in adult males
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nervous system
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• Lhb (luteinizing hormone beta) mRNA levels are significantly increased whereas Fshb (follicle stimulating hormone beta) mRNA levels are significantly reduced in the pituitary of adult males
• however, serum FSH levels are normal in adult males
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| hyperandrogenism | DOID:11613 | J:256588 | ||
