Analysis Tools
growth/size/body
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• 8 week old mice are smaller
• mice supplemented with sodium bicarbonate to normalize serum bicarbonate levels show improved growth
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homeostasis/metabolism
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• lower serum pH
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hypokalemia
(
J:216402
)
|
• lower serum potassium levels
|
|
• distal renal tubular acidosis
|
immune system
|
• mice show increased susceptibility to pyelonephritis following infection with Escherichia coli
|
|
• 24 hours after bacterial inoculation with Escherichia coli strain CFRT073, mutants have a mean bacterial burden that is 5-fold higher in the bladder and 15-fold higher in the kidneys compared to wild-type mice
• mutants are 3 times less likely to clear bacteria from the kidney at 24 hours compared to controls and are 8 times less likely to clear at 48 hours
• mice supplemented with sodium bicarbonate to normalize serum bicarbonate levels show increased bacterial burdens in the bladder
|
renal/urinary system
|
• distal renal tubular acidosis
|
|
• mice show increased susceptibility to pyelonephritis following infection with Escherichia coli
|
|
• 3-fold decrease in intercalated cells in the kidney cortex and medulla
|
