Phenotypes associated with this allele

• Allele Symbol: Plac1^{tm1(KOMP)Vlcg}
• Allele Name: targeted mutation 1, Velocigene
• Allele ID: MGI:3808477
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Plac1^tm1(KOMP)Vlcg/Plac1^tm1(KOMP)Vlcg	C57BL/6N-Plac1^tm1(KOMP)Vlcg	MGI:5433310
ht2	Plac1^tm1(KOMP)Vlcg/Plac1^+	C57BL/6N-Plac1^tm1(KOMP)Vlcg	MGI:5433311
ot3	Plac1^tm1(KOMP)Vlcg/Y	C57BL/6N-Plac1^tm1(KOMP)Vlcg	MGI:5433312

Genotype
MGI:5433310

hm1

• Allelic Composition: Plac1^{tm1(KOMP)Vlcg}/Plac1^{tm1(KOMP)Vlcg}
• Genetic Background: C57BL/6N-Plac1^{tm1(KOMP)Vlcg}
• Cell Lines: 10766D-E3

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Expanded spongiotrophoblast layer in Plac1^{tm1(KOMP)Vlcg}/Plac1⁺ and Plac1^{tm1(KOMP)Vlcg}/Plac1^{tm1(KOMP)Vlcg} placenta

mortality/aging

postnatal lethality, complete penetrance ( J:186550 )

♀ • no females found (only 3 litters examined)

embryo

increased trophoblast giant cell number ( J:186550 )

♀

increased spongiotrophoblast size ( J:186550 )

♀ • expanded

increased placenta weight ( J:186550 )

♀ • at all time points examined compared to wild-type controls

♀ • however, weight is less than that of heterozygous mice with a maternally inherited allele at E15.5 and E16.5

abnormal placenta development ( J:186550 )

♀ • continue to increase in weight after E16.5

Genotype
MGI:5433311

ht2

• Allelic Composition: Plac1^{tm1(KOMP)Vlcg}/Plac1⁺
• Genetic Background: C57BL/6N-Plac1^{tm1(KOMP)Vlcg}
• Cell Lines: 10766D-E3

Placentomegaly and intrauterine growth retardation in Plac1^{tm1(KOMP)Vlcg}/Plac1⁺ mice

embryo

decreased embryo size ( J:186550 )

♀ • when the allele is inherited from the mother the embryos are about 10% smaller compared to wild-type mice at E16.5

increased trophoblast giant cell number ( J:186550 )

♀ • when the allele is inherited from the mother

abnormal placenta junctional zone morphology ( J:186550 )

♀ • when the allele is inherited from the mother the junctional zone is expanded and encroaches into the labyrinth

♀ • however, when the allele is inherited from the father the placenta is similar in morphology to wild-type controls

increased spongiotrophoblast size ( J:186550 )

♀ • expanded when the allele is inherited from the mother

enlarged placenta ( J:186550 )

♀ • when the allele is inherited from the mother the placenta is about twice the size of wild-type placenta at E16.5

♀ • however, when the allele is inherited from the father the placenta is similar in size to wild-type controls

increased placenta weight ( J:186550 )

♀ • from E14.5 - E18.5 when the allele is inherited from the mother

abnormal placenta development ( J:186550 )

♀ • display accelerated weight gain between E12.5 and E14.5 when the allele is inherited from the mother

cellular

paternal imprinting ( J:186550 )

♀ • abnormal phenotypes are seen when the allele is inherited maternally

growth/size/body

decreased embryo size ( J:186550 )

♀ • when the allele is inherited from the mother the embryos are about 10% smaller compared to wild-type mice at E16.5

Genotype
MGI:5433312

ot3

• Allelic Composition: Plac1^{tm1(KOMP)Vlcg}/Y
• Genetic Background: C57BL/6N-Plac1^{tm1(KOMP)Vlcg}
• Cell Lines: 10766D-E3

Abnormal placenta in Plac1^{tm1(KOMP)Vlcg}/Y mice

mortality/aging

postnatal lethality, incomplete penetrance ( J:186550 )

♂ • males are underrepresented at weaning

embryo

increased spongiotrophoblast size ( J:186550 )

♂ • expanded