All Phenotypes Nfasc<tm1.1Brp> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Nfasc^tm1.1Brp
targeted mutation 1.1, Peter J Brophy
MGI:3808598

Summary

9 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Nfasc^tm1.1Brp/Nfasc^tm1.1Brp	B6.129P2-Nfasc^tm1.1Brp	MGI:3808611
hm2	Nfasc^tm1.1Brp/Nfasc^tm1.1Brp	involves: 129P2/OlaHsd * C57BL/6	MGI:3808698
hm3	Nfasc^tm1.1Brp/Nfasc^tm1.1Brp	involves: 129P2/OlaHsd * ICR	MGI:4840025
cn4	Nfasc^tm1.1Brp/Nfasc^tm1.2Brp Tg(Thy1-cre/ERT2)#Brp/0	involves: 129P2/OlaHsd * C57BL/6	MGI:5141310
cx5	Nfasc^tm1.1Brp/Nfasc^tm1.1Brp Tg(Plp1-Nfasc*)1Brp/0	B6.Cg-Nfasc^tm1.1Brp Tg(Plp1-Nfasc*)1Brp	MGI:3808612
cx6	Nfasc^tm1.1Brp/Nfasc^tm1.1Brp Nrcam^tm1Gmt/Nrcam^tm1Gmt	involves: 129P2/OlaHsd * 129S6/SvEvTac * ICR	MGI:4840024
cx7	Nfasc^tm1.1Brp/Nfasc^tm1.1Brp Tg(Nefl-Nfasc)1Brp/0	involves: 129P2/OlaHsd * C57BL/6	MGI:3808702
cx8	Nfasc^tm1.1Brp/Nfasc^tm1.1Brp Tg(Plp1-Nfasc)2Brp/0	involves: 129P2/OlaHsd * C57BL/6	MGI:3808701
cx9	Nfasc^tm1.1Brp/Nfasc^tm1.1Brp Tg(Plp1-Nfasc*)1Brp/0	involves: 129P2/OlaHsd * C57BL/6	MGI:3808699

Allelic Composition	Nfasc^tm1.1Brp/Nfasc^tm1.1Brp
Genetic Background	B6.129P2-Nfasc^tm1.1Brp

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nfasc^tm1.1Brp mutation (0 available); any Nfasc mutation (61 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:107591 )

• mice die 6 to 7 days after birth

nervous system

abnormal sciatic nerve morphology ( J:107591 )

• despite the presence of the appropriate proteins, axoglial structures at the paranode fail to assemble and septate junctions are lost while junctional gaps are widened compared to in wild-type mice

• unlike in wild-type mice, microvillar processes of Schwann cells interdigitate in the gap between axon and glial cell

• however, the overlying myelin sheath appears normal

decreased nerve conduction velocity ( J:107591 )

• in the sciatic nerve

Allelic Composition	Nfasc^tm1.1Brp/Nfasc^tm1.1Brp
Genetic Background	involves: 129P2/OlaHsd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nfasc^tm1.1Brp mutation (0 available); any Nfasc mutation (61 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Reduced myelination in the Nfasc^tm1.1Brp/Nfasc^tm1.1Brp mouse at P6

nervous system

abnormal axon morphology ( J:139185 )

• the number of myelinated axons is decreased at P6 in the ventral funiculus of the cervical spinal cord compared to in wild-type mice

• however, the total numbers of axons and oligodendrocytes are normal

• interheminodal gaps are increased compared to in wild-type mice

• paranodes and nodes are disrupted

abnormal oligodendrocyte physiology ( J:139185 )

• migration of oligodendrocyte processes is impaired compared to in wild-type mice

Allelic Composition	Nfasc^tm1.1Brp/Nfasc^tm1.1Brp
Genetic Background	involves: 129P2/OlaHsd * ICR

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nfasc^tm1.1Brp mutation (0 available); any Nfasc mutation (61 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:166099 )

• at P7

nervous system

abnormal axon morphology ( J:166099 )

• nodes fail to form in myelinating coculture of dorsal root ganglia neurons and Schwann cells unlike wild-type cultures

• nodes and heminodes fail to form unlike in wild-type mice

behavior/neurological

paralysis ( J:166099 )

Allelic Composition	Nfasc^tm1.1Brp/Nfasc^tm1.2Brp Tg(Thy1-cre/ERT2)#Brp/0
Genetic Background	involves: 129P2/OlaHsd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nfasc^tm1.1Brp mutation (0 available); any Nfasc mutation (61 available)
Nfasc^tm1.2Brp mutation (0 available); any Nfasc mutation (61 available)
Tg(Thy1-cre/ERT2)#Brp mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

nervous system phenotype ( J:174740 )

N	• central nervous system nodes of Ranvier remain intact after tamoxifen treatment

abnormal axon initial segment morphology ( J:174740 )

• Purkinje cells from tamoxifen-treated mice exhibit axon initial segment disintegration compared with control mice

abnormal synapse morphology ( J:174740 )

• after 16 weeks, Purkinje cells from tamoxifen-treated mice lack pinceau synapses or exhibit reduced pinceau synapse size compared with control mice

abnormal action potential ( J:174740 )

• Purkinje cells tamoxifen-treated mice require a greater current to drive spike firing compared with control mice

• wave-form of action potential exhibit reduced maximum rate of rise and peak amplitude and increased half-width and delay until peak of the afterhyperpolarization potential compared to in control cells

impaired ability to fire action potentials ( J:174740 )

• Purkinje cells of tamoxifen-treated mice fail to maintain spontaneous action potential firing and instead maintain a modal resting potential compared with control cells

behavior/neurological

impaired balance ( J:174740 )

• at 6 weeks, tamoxifen-treated mice exhibit impaired performance and balance on a rotarod compared with wild-type mice

impaired coordination ( J:174740 )

• at 6 weeks, tamoxifen-treated mice exhibit impaired performance and balance on a rotarod compared with wild-type mice

abnormal gait ( J:174740 )

• in tamoxifen-treated mice at 6 weeks

Allelic Composition	Nfasc^tm1.1Brp/Nfasc^tm1.1Brp Tg(Plp1-Nfasc*)1Brp/0
Genetic Background	B6.Cg-Nfasc^tm1.1Brp Tg(Plp1-Nfasc*)1Brp

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nfasc^tm1.1Brp mutation (0 available); any Nfasc mutation (61 available)
Tg(Plp1-Nfasc*)1Brp mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal sciatic nerve morphology ( J:107591 )

• despite the re-establishment of paranodal junctional complexes, the node complex is not rescued

Allelic Composition	Nfasc^tm1.1Brp/Nfasc^tm1.1Brp Nrcam^tm1Gmt/Nrcam^tm1Gmt
Genetic Background	involves: 129P2/OlaHsd * 129S6/SvEvTac * ICR

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nfasc^tm1.1Brp mutation (0 available); any Nfasc mutation (61 available)
Nrcam^tm1Gmt mutation (1 available); any Nrcam mutation (87 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal axon morphology ( J:166099 )

• sodium ion channels are absent from heminodes unlike in wild-type mice

Allelic Composition	Nfasc^tm1.1Brp/Nfasc^tm1.1Brp Tg(Nefl-Nfasc)1Brp/0
Genetic Background	involves: 129P2/OlaHsd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nfasc^tm1.1Brp mutation (0 available); any Nfasc mutation (61 available)
Tg(Nefl-Nfasc)1Brp mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:139185 )

• despite surviving beyond day 6 to 7, mice die by 18 to 19 days after birth

nervous system

nervous system phenotype ( J:139185 )

N	• mice exhibit normal paranodal and nodal complex formation in the peripheral and central nervous system and normal localization of sodium channels to the nodes

abnormal axon morphology ( J:139185 )

• interheminodal gaps are increased compared to in wild-type mice

abnormal oligodendrocyte physiology ( J:139185 )

• migration of oligodendrocyte processes is delayed compared to in wild-type mice with increased interheminodal gaps

• however, by P16 interheminodal gaps are normal

Allelic Composition	Nfasc^tm1.1Brp/Nfasc^tm1.1Brp Tg(Plp1-Nfasc)2Brp/0
Genetic Background	involves: 129P2/OlaHsd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nfasc^tm1.1Brp mutation (0 available); any Nfasc mutation (61 available)
Tg(Plp1-Nfasc)2Brp mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

nervous system phenotype ( J:139185 )

N	• axoglial junctions in the central and peripheral nervous system and sodium channel localization to nodes in the central nervous system are normal

abnormal axon morphology ( J:139185 )

• mice exhibit altered sodium channel localization within axons in the peripheral nervous system

Allelic Composition	Nfasc^tm1.1Brp/Nfasc^tm1.1Brp Tg(Plp1-Nfasc*)1Brp/0
Genetic Background	involves: 129P2/OlaHsd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nfasc^tm1.1Brp mutation (0 available); any Nfasc mutation (61 available)
Tg(Plp1-Nfasc*)1Brp mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

nervous system phenotype ( J:139185 )

N	• mice exhibit normal interheminodal gaps, oligodendrocyte process migration and localization of sodium channels to the nodes in the central nervous system

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