Phenotypes associated with this allele

• Allele Symbol: Tg(Plp1-Nfasc*)1Brp
• Allele Name: transgene insertion 1, Peter J Brophy
• Allele ID: MGI:3808610
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Nfasc^tm1.1Brp/Nfasc^tm1.1Brp Tg(Plp1-Nfasc*)1Brp/0	B6.Cg-Nfasc^tm1.1Brp Tg(Plp1-Nfasc*)1Brp	MGI:3808612
cx2	Nfasc^tm1.1Brp/Nfasc^tm1.1Brp Tg(Plp1-Nfasc*)1Brp/0	involves: 129P2/OlaHsd * C57BL/6	MGI:3808699

Genotype
MGI:3808612

cx1

• Allelic Composition: Nfasc^tm1.1Brp/Nfasc^tm1.1Brp; Tg(Plp1-Nfasc*)1Brp/0
• Genetic Background: B6.Cg-Nfasc^tm1.1Brp Tg(Plp1-Nfasc*)1Brp

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal sciatic nerve morphology ( J:107591 )

• despite the re-establishment of paranodal junctional complexes, the node complex is not rescued

Genotype
MGI:3808699

cx2

• Allelic Composition: Nfasc^tm1.1Brp/Nfasc^tm1.1Brp; Tg(Plp1-Nfasc*)1Brp/0
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

nervous system

nervous system phenotype ( J:139185 )

N • mice exhibit normal interheminodal gaps, oligodendrocyte process migration and localization of sodium channels to the nodes in the central nervous system